Eicosanoids and rheumatology: Inflammatory and vascular aspects

    Research output: Contribution to journalArticle

    42 Citations (Scopus)

    Abstract

    Eicosanoids are not only involved in inflammation but also are important in the maintenance of blood vessel tone and blood flow. This may be relevant in the rheumatological disorders of vasculitis and RS. Although little work has been carried out in vasculitis, the beneficial effects of the natural and synthetic antiplatelet vasodilator PGs in RS are well documented. Less well tested has been the effects of manipulation of AA metabolism.

    It should be remembered however that many patients with Raynaud's Phenomenon do not have an associated rheumatological disorder. Conservative management with vasodilators such as the calcium channel blockers may be very successful (119). At the present time PG treatment should be reserved for patients with severe RS, particularly those whose raynaud's is complicated by digital ulceration.
    Original languageEnglish
    Pages (from-to)219-234
    Number of pages16
    JournalProstaglandins, Leukotrienes, and Essential Fatty Acids
    Volume36
    Issue number4
    DOIs
    Publication statusPublished - Jun 1989

    Fingerprint

    Eicosanoids
    Rheumatology
    Vasculitis
    Vasodilator Agents
    Blood Vessels
    Raynaud Disease
    Blood vessels
    Calcium Channel Blockers
    Metabolism
    Blood
    Maintenance
    Inflammation
    Therapeutics
    Conservative Treatment

    Cite this

    @article{98f26d35bc4b4efba4308cbc188f7f09,
    title = "Eicosanoids and rheumatology: Inflammatory and vascular aspects",
    abstract = "Eicosanoids are not only involved in inflammation but also are important in the maintenance of blood vessel tone and blood flow. This may be relevant in the rheumatological disorders of vasculitis and RS. Although little work has been carried out in vasculitis, the beneficial effects of the natural and synthetic antiplatelet vasodilator PGs in RS are well documented. Less well tested has been the effects of manipulation of AA metabolism.It should be remembered however that many patients with Raynaud's Phenomenon do not have an associated rheumatological disorder. Conservative management with vasodilators such as the calcium channel blockers may be very successful (119). At the present time PG treatment should be reserved for patients with severe RS, particularly those whose raynaud's is complicated by digital ulceration.",
    author = "Belch, {J. J. F.}",
    year = "1989",
    month = "6",
    doi = "10.1016/0952-3278(89)90135-X",
    language = "English",
    volume = "36",
    pages = "219--234",
    journal = "Prostaglandins, Leukotrienes, and Essential Fatty Acids",
    issn = "0952-3278",
    publisher = "Elsevier",
    number = "4",

    }

    Eicosanoids and rheumatology : Inflammatory and vascular aspects. / Belch, J. J. F.

    In: Prostaglandins, Leukotrienes, and Essential Fatty Acids, Vol. 36, No. 4, 06.1989, p. 219-234.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Eicosanoids and rheumatology

    T2 - Inflammatory and vascular aspects

    AU - Belch, J. J. F.

    PY - 1989/6

    Y1 - 1989/6

    N2 - Eicosanoids are not only involved in inflammation but also are important in the maintenance of blood vessel tone and blood flow. This may be relevant in the rheumatological disorders of vasculitis and RS. Although little work has been carried out in vasculitis, the beneficial effects of the natural and synthetic antiplatelet vasodilator PGs in RS are well documented. Less well tested has been the effects of manipulation of AA metabolism.It should be remembered however that many patients with Raynaud's Phenomenon do not have an associated rheumatological disorder. Conservative management with vasodilators such as the calcium channel blockers may be very successful (119). At the present time PG treatment should be reserved for patients with severe RS, particularly those whose raynaud's is complicated by digital ulceration.

    AB - Eicosanoids are not only involved in inflammation but also are important in the maintenance of blood vessel tone and blood flow. This may be relevant in the rheumatological disorders of vasculitis and RS. Although little work has been carried out in vasculitis, the beneficial effects of the natural and synthetic antiplatelet vasodilator PGs in RS are well documented. Less well tested has been the effects of manipulation of AA metabolism.It should be remembered however that many patients with Raynaud's Phenomenon do not have an associated rheumatological disorder. Conservative management with vasodilators such as the calcium channel blockers may be very successful (119). At the present time PG treatment should be reserved for patients with severe RS, particularly those whose raynaud's is complicated by digital ulceration.

    U2 - 10.1016/0952-3278(89)90135-X

    DO - 10.1016/0952-3278(89)90135-X

    M3 - Article

    VL - 36

    SP - 219

    EP - 234

    JO - Prostaglandins, Leukotrienes, and Essential Fatty Acids

    JF - Prostaglandins, Leukotrienes, and Essential Fatty Acids

    SN - 0952-3278

    IS - 4

    ER -