Electroconvulsivestimulation and synapticplasticity in the rat

Caroline Stewart; Ian Reid

doi:10.1016/0006-8993(93)90280-Z

Electroconvulsivestimulation and synapticplasticity in the rat

Caroline Stewart, Ian Reid

Research output: Contribution to journal › Comment/debate › peer-review

64 Citations (Scopus)

Abstract

The effects of repeated, spaced, electroconvulsive stimulation (ECS) on rodent hippocampal synaptic plasticity was investigated in vivo. Long-term potentiation (LTP) was induced in intact rats using high-frequency perforant path stimulation, and measured by recording extracellular excitatory field potentials and population spikes evoked in the dentate gyrus by low-frequency stimulation before and after LTP induction. LTP induction appeared to be inhibited in animals which had received ECS. However, inspection and analysis of absolute excitatory postsynaptic potential and population spike size before LTP induction in ECS treated animals suggested that LTP may have already been induced as a consequence of seizure activity, reducing the degree to which further potentiation could be elicited experimentally.

Original language	English
Pages (from-to)	139-141
Number of pages	3
Journal	Brain Research
Volume	620
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(93)90280-Z
Publication status	Published - 20 Aug 1993

Keywords

Electroconvulsive stimulation
Long-term potentiation
Hippocampus
Memory
Depressive illness

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10.1016/0006-8993(93)90280-Z

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title = "Electroconvulsivestimulation and synapticplasticity in the rat",

abstract = "The effects of repeated, spaced, electroconvulsive stimulation (ECS) on rodent hippocampal synaptic plasticity was investigated in vivo. Long-term potentiation (LTP) was induced in intact rats using high-frequency perforant path stimulation, and measured by recording extracellular excitatory field potentials and population spikes evoked in the dentate gyrus by low-frequency stimulation before and after LTP induction. LTP induction appeared to be inhibited in animals which had received ECS. However, inspection and analysis of absolute excitatory postsynaptic potential and population spike size before LTP induction in ECS treated animals suggested that LTP may have already been induced as a consequence of seizure activity, reducing the degree to which further potentiation could be elicited experimentally.",

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AU - Stewart, Caroline

AU - Reid, Ian

PY - 1993/8/20

Y1 - 1993/8/20

N2 - The effects of repeated, spaced, electroconvulsive stimulation (ECS) on rodent hippocampal synaptic plasticity was investigated in vivo. Long-term potentiation (LTP) was induced in intact rats using high-frequency perforant path stimulation, and measured by recording extracellular excitatory field potentials and population spikes evoked in the dentate gyrus by low-frequency stimulation before and after LTP induction. LTP induction appeared to be inhibited in animals which had received ECS. However, inspection and analysis of absolute excitatory postsynaptic potential and population spike size before LTP induction in ECS treated animals suggested that LTP may have already been induced as a consequence of seizure activity, reducing the degree to which further potentiation could be elicited experimentally.

AB - The effects of repeated, spaced, electroconvulsive stimulation (ECS) on rodent hippocampal synaptic plasticity was investigated in vivo. Long-term potentiation (LTP) was induced in intact rats using high-frequency perforant path stimulation, and measured by recording extracellular excitatory field potentials and population spikes evoked in the dentate gyrus by low-frequency stimulation before and after LTP induction. LTP induction appeared to be inhibited in animals which had received ECS. However, inspection and analysis of absolute excitatory postsynaptic potential and population spike size before LTP induction in ECS treated animals suggested that LTP may have already been induced as a consequence of seizure activity, reducing the degree to which further potentiation could be elicited experimentally.

KW - Electroconvulsive stimulation

KW - Long-term potentiation

KW - Hippocampus

KW - Memory

KW - Depressive illness

U2 - 10.1016/0006-8993(93)90280-Z

DO - 10.1016/0006-8993(93)90280-Z

M3 - Comment/debate

SN - 0006-8993

VL - 620

SP - 139

EP - 141

JO - Brain Research

JF - Brain Research

IS - 1

ER -

Electroconvulsivestimulation and synapticplasticity in the rat

Abstract

Keywords

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