Abstract
Recent reports attributing antiemetic, anxiolytic and antipsychotic properties to selective 5-HT3 receptor antagonists, combined with the identification by radioligand binding techniques of 5-HT3 recognition sites in the mammalian CNS, have led to an intensification of research into the properties of the 5-HT a receptor subtype. Model systems that may be particularly useful in elucidating the details of the interaction of 5-HT with 5-HT3 receptors at the molecular level include certain neuronal clonal cell lines and primary cultures of central and peruipheral neurones.
| Original language | English |
|---|---|
| Pages (from-to) | 172-175 |
| Number of pages | 4 |
| Journal | Trends in Pharmacological Sciences |
| Volume | 10 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 1989 |
Keywords
- (3α-tropanyl)-1H-indole-3-carboxylic acid ester
- 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl-1H-imidazol-1-yl)methyl]-H-carbazol-4-one
- 1αH,3α,5αH-tropan-3-yl-3,5-dichlorobenzoate
- 3-(5-methyl-lH-imidazol-4-yl)-1-(1-methyl-1H-indol-3-yl)-1-propanone
- GR-38032F
- GR-65630
- ICS 205-930
- MDL-72222
ASJC Scopus subject areas
- Pharmacology
- Toxicology