Recent reports attributing antiemetic, anxiolytic and antipsychotic properties to selective 5-HT3 receptor antagonists, combined with the identification by radioligand binding techniques of 5-HT3 recognition sites in the mammalian CNS, have led to an intensification of research into the properties of the 5-HT a receptor subtype. Model systems that may be particularly useful in elucidating the details of the interaction of 5-HT with 5-HT3 receptors at the molecular level include certain neuronal clonal cell lines and primary cultures of central and peruipheral neurones.
|Number of pages||4|
|Journal||Trends in Pharmacological Sciences|
|Publication status||Published - May 1989|
- (3α-tropanyl)-1H-indole-3-carboxylic acid ester
- ICS 205-930
ASJC Scopus subject areas