Electrophysiology of 5-HT3 receptors in neuronal cell lines

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Recent reports attributing antiemetic, anxiolytic and antipsychotic properties to selective 5-HT3 receptor antagonists, combined with the identification by radioligand binding techniques of 5-HT3 recognition sites in the mammalian CNS, have led to an intensification of research into the properties of the 5-HT a receptor subtype. Model systems that may be particularly useful in elucidating the details of the interaction of 5-HT with 5-HT3 receptors at the molecular level include certain neuronal clonal cell lines and primary cultures of central and peruipheral neurones.
Original languageEnglish
Pages (from-to)172-175
Number of pages4
JournalTrends in Pharmacological Sciences
Volume10
Issue number5
DOIs
Publication statusPublished - May 1989

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Electrophysiology
Receptors, Serotonin, 5-HT3
Serotonin
Cells
Serotonin 5-HT3 Receptor Antagonists
Cell Line
Antiemetics
Serotonin Receptors
Anti-Anxiety Agents
Cell culture
Antipsychotic Agents
Neurons
Research

Keywords

  • (3α-tropanyl)-1H-indole-3-carboxylic acid ester
  • 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl-1H-imidazol-1-yl)methyl]-H-carbazol-4-one
  • 1αH,3α,5αH-tropan-3-yl-3,5-dichlorobenzoate
  • 3-(5-methyl-lH-imidazol-4-yl)-1-(1-methyl-1H-indol-3-yl)-1-propanone
  • GR-38032F
  • GR-65630
  • ICS 205-930
  • MDL-72222

Cite this

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title = "Electrophysiology of 5-HT3 receptors in neuronal cell lines",
abstract = "Recent reports attributing antiemetic, anxiolytic and antipsychotic properties to selective 5-HT3 receptor antagonists, combined with the identification by radioligand binding techniques of 5-HT3 recognition sites in the mammalian CNS, have led to an intensification of research into the properties of the 5-HT a receptor subtype. Model systems that may be particularly useful in elucidating the details of the interaction of 5-HT with 5-HT3 receptors at the molecular level include certain neuronal clonal cell lines and primary cultures of central and peruipheral neurones.",
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author = "Peters, {John A.} and Lambert, {Jeremy J.}",
year = "1989",
month = "5",
doi = "10.1016/0165-6147(89)90230-7",
language = "English",
volume = "10",
pages = "172--175",
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Electrophysiology of 5-HT3 receptors in neuronal cell lines. / Peters, John A.; Lambert, Jeremy J.

In: Trends in Pharmacological Sciences, Vol. 10, No. 5, 05.1989, p. 172-175.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Electrophysiology of 5-HT3 receptors in neuronal cell lines

AU - Peters, John A.

AU - Lambert, Jeremy J.

PY - 1989/5

Y1 - 1989/5

N2 - Recent reports attributing antiemetic, anxiolytic and antipsychotic properties to selective 5-HT3 receptor antagonists, combined with the identification by radioligand binding techniques of 5-HT3 recognition sites in the mammalian CNS, have led to an intensification of research into the properties of the 5-HT a receptor subtype. Model systems that may be particularly useful in elucidating the details of the interaction of 5-HT with 5-HT3 receptors at the molecular level include certain neuronal clonal cell lines and primary cultures of central and peruipheral neurones.

AB - Recent reports attributing antiemetic, anxiolytic and antipsychotic properties to selective 5-HT3 receptor antagonists, combined with the identification by radioligand binding techniques of 5-HT3 recognition sites in the mammalian CNS, have led to an intensification of research into the properties of the 5-HT a receptor subtype. Model systems that may be particularly useful in elucidating the details of the interaction of 5-HT with 5-HT3 receptors at the molecular level include certain neuronal clonal cell lines and primary cultures of central and peruipheral neurones.

KW - (3α-tropanyl)-1H-indole-3-carboxylic acid ester

KW - 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl-1H-imidazol-1-yl)methyl]-H-carbazol-4-one

KW - 1αH,3α,5αH-tropan-3-yl-3,5-dichlorobenzoate

KW - 3-(5-methyl-lH-imidazol-4-yl)-1-(1-methyl-1H-indol-3-yl)-1-propanone

KW - GR-38032F

KW - GR-65630

KW - ICS 205-930

KW - MDL-72222

U2 - 10.1016/0165-6147(89)90230-7

DO - 10.1016/0165-6147(89)90230-7

M3 - Article

C2 - 2667222

AN - SCOPUS:0024472716

VL - 10

SP - 172

EP - 175

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

SN - 0165-6147

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ER -