Electrophysiology of 5-HT3 receptors in neuronal cell lines

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85 Citations (Scopus)


Recent reports attributing antiemetic, anxiolytic and antipsychotic properties to selective 5-HT3 receptor antagonists, combined with the identification by radioligand binding techniques of 5-HT3 recognition sites in the mammalian CNS, have led to an intensification of research into the properties of the 5-HT a receptor subtype. Model systems that may be particularly useful in elucidating the details of the interaction of 5-HT with 5-HT3 receptors at the molecular level include certain neuronal clonal cell lines and primary cultures of central and peruipheral neurones.
Original languageEnglish
Pages (from-to)172-175
Number of pages4
JournalTrends in Pharmacological Sciences
Issue number5
Publication statusPublished - May 1989


  • (3α-tropanyl)-1H-indole-3-carboxylic acid ester
  • 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl-1H-imidazol-1-yl)methyl]-H-carbazol-4-one
  • 1αH,3α,5αH-tropan-3-yl-3,5-dichlorobenzoate
  • 3-(5-methyl-lH-imidazol-4-yl)-1-(1-methyl-1H-indol-3-yl)-1-propanone
  • GR-38032F
  • GR-65630
  • ICS 205-930
  • MDL-72222

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology


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