Elevated levels of sE-selectin in post-menopausal females are decreased by hormone replacement therapy to levels observed in pre-menopausal females

Gwen Kennedy, Margaret McLaren, Jill J. F. Belch, Mary Seed

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    Observational epidemological studies have shown that mortality from coronary heart disease is reduced in post-menopausal women by hormone replacement therapy (HRT). The aim of this study was to measure sE-selectin levels in post-menopausal females before and after HRT and to compare these with pre-menopausal females and aged matched males. Post-menopausal females (n = 70) were given HRT or no treatment to act as a control group. sE-selectin levels were significantly lower in the pre-menopausal (n = 36) when compared with the post-menopausal females (n = 70) (p = 0.027), whereas no difference between two age matched male groups was found (n = 40). Oral and transdermal HRT significantly decreased sE-selectin levels (p <0.0001and p = 0.0005 respectively) with no change in the control group. The reduction in the levels of this marker of endothelial activation after HRT, may reflect a decrease in leucocyte/endothelial interaction which may reduce atherosclerotic risk in post-menopausal females.
    Original languageEnglish
    Pages (from-to)1433-1436
    Number of pages4
    JournalThrombosis and Haemostasis
    Volume82
    Issue number5
    Publication statusPublished - Nov 1999

    Fingerprint

    Selectins
    Hormone Replacement Therapy
    Control Groups
    Estrogen Replacement Therapy
    Observational Studies
    Coronary Disease
    Leukocytes
    Research Design
    Mortality

    Cite this

    @article{cef83dfe6e89415793db311ee5a1c666,
    title = "Elevated levels of sE-selectin in post-menopausal females are decreased by hormone replacement therapy to levels observed in pre-menopausal females",
    abstract = "Observational epidemological studies have shown that mortality from coronary heart disease is reduced in post-menopausal women by hormone replacement therapy (HRT). The aim of this study was to measure sE-selectin levels in post-menopausal females before and after HRT and to compare these with pre-menopausal females and aged matched males. Post-menopausal females (n = 70) were given HRT or no treatment to act as a control group. sE-selectin levels were significantly lower in the pre-menopausal (n = 36) when compared with the post-menopausal females (n = 70) (p = 0.027), whereas no difference between two age matched male groups was found (n = 40). Oral and transdermal HRT significantly decreased sE-selectin levels (p <0.0001and p = 0.0005 respectively) with no change in the control group. The reduction in the levels of this marker of endothelial activation after HRT, may reflect a decrease in leucocyte/endothelial interaction which may reduce atherosclerotic risk in post-menopausal females.",
    author = "Gwen Kennedy and Margaret McLaren and Belch, {Jill J. F.} and Mary Seed",
    year = "1999",
    month = "11",
    language = "English",
    volume = "82",
    pages = "1433--1436",
    journal = "Thrombosis and Haemostasis",
    issn = "0340-6245",
    publisher = "Schattauer Publishers",
    number = "5",

    }

    TY - JOUR

    T1 - Elevated levels of sE-selectin in post-menopausal females are decreased by hormone replacement therapy to levels observed in pre-menopausal females

    AU - Kennedy, Gwen

    AU - McLaren, Margaret

    AU - Belch, Jill J. F.

    AU - Seed, Mary

    PY - 1999/11

    Y1 - 1999/11

    N2 - Observational epidemological studies have shown that mortality from coronary heart disease is reduced in post-menopausal women by hormone replacement therapy (HRT). The aim of this study was to measure sE-selectin levels in post-menopausal females before and after HRT and to compare these with pre-menopausal females and aged matched males. Post-menopausal females (n = 70) were given HRT or no treatment to act as a control group. sE-selectin levels were significantly lower in the pre-menopausal (n = 36) when compared with the post-menopausal females (n = 70) (p = 0.027), whereas no difference between two age matched male groups was found (n = 40). Oral and transdermal HRT significantly decreased sE-selectin levels (p <0.0001and p = 0.0005 respectively) with no change in the control group. The reduction in the levels of this marker of endothelial activation after HRT, may reflect a decrease in leucocyte/endothelial interaction which may reduce atherosclerotic risk in post-menopausal females.

    AB - Observational epidemological studies have shown that mortality from coronary heart disease is reduced in post-menopausal women by hormone replacement therapy (HRT). The aim of this study was to measure sE-selectin levels in post-menopausal females before and after HRT and to compare these with pre-menopausal females and aged matched males. Post-menopausal females (n = 70) were given HRT or no treatment to act as a control group. sE-selectin levels were significantly lower in the pre-menopausal (n = 36) when compared with the post-menopausal females (n = 70) (p = 0.027), whereas no difference between two age matched male groups was found (n = 40). Oral and transdermal HRT significantly decreased sE-selectin levels (p <0.0001and p = 0.0005 respectively) with no change in the control group. The reduction in the levels of this marker of endothelial activation after HRT, may reflect a decrease in leucocyte/endothelial interaction which may reduce atherosclerotic risk in post-menopausal females.

    M3 - Article

    C2 - 10595633

    VL - 82

    SP - 1433

    EP - 1436

    JO - Thrombosis and Haemostasis

    JF - Thrombosis and Haemostasis

    SN - 0340-6245

    IS - 5

    ER -