Elevated levels of soluble E-selectin in diabetic patients with severe symptomatic peripheral arterial occlusive disease requiring angioplasty: a possible role in diabetic vascular disease?

T. A. Elhadd, G. Kennedy, M. McLaren, P. A. Stonebridge, W. J. Shaw, J. J. F. Belch

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    Back­ground. To study lev­els of E-selec­tin in ­patients with periph­er­al arte­ri­al occlu­sive dis­ease who were under­go­ing per­cut­ane­ous trans­lu­mi­nal angio­plas­ty.
    Meth­ods.?Experi­men­tal ­design and set­ting: Cross sec­tion­al case con­trol study, con­duct­ed in a teach­ing hos­pi­tal. Sub­jects: Seven ­patients with type-2 (non-insu­lin depen­dent) dia­betes mel­lit­us under­go­ing trans­lu­mi­nal angio­plas­ty for symp­to­mat­ic periph­er­al arte­ri­al occlu­sive dis­ease, had blood tests for sE-selec­tin meas­ure­ment, and were com­pared to a sim­i­lar ­groups of age and sex ­matched non-dia­bet­ic ­patients with arter­i­op­a­thy who are under­go­ing the same pro­ce­dure. Also eval­u­at­ed were a group of dia­bet­ic ­patients and ­healthy non-dia­bet­ics with no periph­er­al arte­ri­al dis­ease.
    ­Results.?The lev­els of sE-selec­tin in the two dia­bet­ic ­groups were sig­nif­i­cant­ly high­er than the non-dia­bet­ic ­groups meas­ur­ing at 77 ng/ml (53-120) and 79 ng/ml (43-98) (­median, range) vs 54 ng/ml (24-104) in the non-dia­bet­ic with arter­i­op­a­thy, and 42 ng/ml (35-66) in the nor­mal ­healthy con­trols, p<0.04, p<0.003 respec­tive­ly, Mann Whit­ney “U” test.
    Con­clu­sions. We have dem­on­strat­ed sig­nif­i­cant­ly high val­ues of sol­u­ble E-selec­tin in ­patients with dia­betes mel­lit­us requir­ing angio­plas­ty for symp­to­mat­ic periph­er­al arte­ri­al occlu­sive dis­ease. This sug­gests that sE-selec­tin may be ­involved in the dia­bet­ic angio­path­ic pro­cess. It may act as a pre­cur­sor for ­smooth mus­cle pro­life­ra­tion.
    Original languageEnglish
    Pages (from-to)171-175
    Number of pages5
    JournalInternational Angiology
    Volume19
    Issue number2
    Publication statusPublished - Jun 2000

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    Diabetic Angiopathies
    Arterial Occlusive Diseases
    E-Selectin
    Peripheral Arterial Disease
    Angioplasty
    Selectins
    Hematologic Tests
    Nonparametric Statistics
    Teaching Hospitals
    Type 2 Diabetes Mellitus
    Smooth Muscle
    Case-Control Studies
    Diabetes Mellitus
    Research Design
    Age Groups

    Cite this

    @article{6494c224305d48579f9f0dd18238603a,
    title = "Elevated levels of soluble E-selectin in diabetic patients with severe symptomatic peripheral arterial occlusive disease requiring angioplasty: a possible role in diabetic vascular disease?",
    abstract = "Back­ground. To study lev­els of E-selec­tin in ­patients with periph­er­al arte­ri­al occlu­sive dis­ease who were under­go­ing per­cut­ane­ous trans­lu­mi­nal angio­plas­ty.Meth­ods.?Experi­men­tal ­design and set­ting: Cross sec­tion­al case con­trol study, con­duct­ed in a teach­ing hos­pi­tal. Sub­jects: Seven ­patients with type-2 (non-insu­lin depen­dent) dia­betes mel­lit­us under­go­ing trans­lu­mi­nal angio­plas­ty for symp­to­mat­ic periph­er­al arte­ri­al occlu­sive dis­ease, had blood tests for sE-selec­tin meas­ure­ment, and were com­pared to a sim­i­lar ­groups of age and sex ­matched non-dia­bet­ic ­patients with arter­i­op­a­thy who are under­go­ing the same pro­ce­dure. Also eval­u­at­ed were a group of dia­bet­ic ­patients and ­healthy non-dia­bet­ics with no periph­er­al arte­ri­al dis­ease.­Results.?The lev­els of sE-selec­tin in the two dia­bet­ic ­groups were sig­nif­i­cant­ly high­er than the non-dia­bet­ic ­groups meas­ur­ing at 77 ng/ml (53-120) and 79 ng/ml (43-98) (­median, range) vs 54 ng/ml (24-104) in the non-dia­bet­ic with arter­i­op­a­thy, and 42 ng/ml (35-66) in the nor­mal ­healthy con­trols, p<0.04, p<0.003 respec­tive­ly, Mann Whit­ney “U” test.Con­clu­sions. We have dem­on­strat­ed sig­nif­i­cant­ly high val­ues of sol­u­ble E-selec­tin in ­patients with dia­betes mel­lit­us requir­ing angio­plas­ty for symp­to­mat­ic periph­er­al arte­ri­al occlu­sive dis­ease. This sug­gests that sE-selec­tin may be ­involved in the dia­bet­ic angio­path­ic pro­cess. It may act as a pre­cur­sor for ­smooth mus­cle pro­life­ra­tion.",
    author = "Elhadd, {T. A.} and G. Kennedy and M. McLaren and Stonebridge, {P. A.} and Shaw, {W. J.} and Belch, {J. J. F.}",
    year = "2000",
    month = "6",
    language = "English",
    volume = "19",
    pages = "171--175",
    journal = "International Angiology",
    issn = "0392-9590",
    publisher = "SAGE Publications",
    number = "2",

    }

    TY - JOUR

    T1 - Elevated levels of soluble E-selectin in diabetic patients with severe symptomatic peripheral arterial occlusive disease requiring angioplasty

    T2 - a possible role in diabetic vascular disease?

    AU - Elhadd, T. A.

    AU - Kennedy, G.

    AU - McLaren, M.

    AU - Stonebridge, P. A.

    AU - Shaw, W. J.

    AU - Belch, J. J. F.

    PY - 2000/6

    Y1 - 2000/6

    N2 - Back­ground. To study lev­els of E-selec­tin in ­patients with periph­er­al arte­ri­al occlu­sive dis­ease who were under­go­ing per­cut­ane­ous trans­lu­mi­nal angio­plas­ty.Meth­ods.?Experi­men­tal ­design and set­ting: Cross sec­tion­al case con­trol study, con­duct­ed in a teach­ing hos­pi­tal. Sub­jects: Seven ­patients with type-2 (non-insu­lin depen­dent) dia­betes mel­lit­us under­go­ing trans­lu­mi­nal angio­plas­ty for symp­to­mat­ic periph­er­al arte­ri­al occlu­sive dis­ease, had blood tests for sE-selec­tin meas­ure­ment, and were com­pared to a sim­i­lar ­groups of age and sex ­matched non-dia­bet­ic ­patients with arter­i­op­a­thy who are under­go­ing the same pro­ce­dure. Also eval­u­at­ed were a group of dia­bet­ic ­patients and ­healthy non-dia­bet­ics with no periph­er­al arte­ri­al dis­ease.­Results.?The lev­els of sE-selec­tin in the two dia­bet­ic ­groups were sig­nif­i­cant­ly high­er than the non-dia­bet­ic ­groups meas­ur­ing at 77 ng/ml (53-120) and 79 ng/ml (43-98) (­median, range) vs 54 ng/ml (24-104) in the non-dia­bet­ic with arter­i­op­a­thy, and 42 ng/ml (35-66) in the nor­mal ­healthy con­trols, p<0.04, p<0.003 respec­tive­ly, Mann Whit­ney “U” test.Con­clu­sions. We have dem­on­strat­ed sig­nif­i­cant­ly high val­ues of sol­u­ble E-selec­tin in ­patients with dia­betes mel­lit­us requir­ing angio­plas­ty for symp­to­mat­ic periph­er­al arte­ri­al occlu­sive dis­ease. This sug­gests that sE-selec­tin may be ­involved in the dia­bet­ic angio­path­ic pro­cess. It may act as a pre­cur­sor for ­smooth mus­cle pro­life­ra­tion.

    AB - Back­ground. To study lev­els of E-selec­tin in ­patients with periph­er­al arte­ri­al occlu­sive dis­ease who were under­go­ing per­cut­ane­ous trans­lu­mi­nal angio­plas­ty.Meth­ods.?Experi­men­tal ­design and set­ting: Cross sec­tion­al case con­trol study, con­duct­ed in a teach­ing hos­pi­tal. Sub­jects: Seven ­patients with type-2 (non-insu­lin depen­dent) dia­betes mel­lit­us under­go­ing trans­lu­mi­nal angio­plas­ty for symp­to­mat­ic periph­er­al arte­ri­al occlu­sive dis­ease, had blood tests for sE-selec­tin meas­ure­ment, and were com­pared to a sim­i­lar ­groups of age and sex ­matched non-dia­bet­ic ­patients with arter­i­op­a­thy who are under­go­ing the same pro­ce­dure. Also eval­u­at­ed were a group of dia­bet­ic ­patients and ­healthy non-dia­bet­ics with no periph­er­al arte­ri­al dis­ease.­Results.?The lev­els of sE-selec­tin in the two dia­bet­ic ­groups were sig­nif­i­cant­ly high­er than the non-dia­bet­ic ­groups meas­ur­ing at 77 ng/ml (53-120) and 79 ng/ml (43-98) (­median, range) vs 54 ng/ml (24-104) in the non-dia­bet­ic with arter­i­op­a­thy, and 42 ng/ml (35-66) in the nor­mal ­healthy con­trols, p<0.04, p<0.003 respec­tive­ly, Mann Whit­ney “U” test.Con­clu­sions. We have dem­on­strat­ed sig­nif­i­cant­ly high val­ues of sol­u­ble E-selec­tin in ­patients with dia­betes mel­lit­us requir­ing angio­plas­ty for symp­to­mat­ic periph­er­al arte­ri­al occlu­sive dis­ease. This sug­gests that sE-selec­tin may be ­involved in the dia­bet­ic angio­path­ic pro­cess. It may act as a pre­cur­sor for ­smooth mus­cle pro­life­ra­tion.

    M3 - Article

    C2 - 10905802

    VL - 19

    SP - 171

    EP - 175

    JO - International Angiology

    JF - International Angiology

    SN - 0392-9590

    IS - 2

    ER -