Projects per year
Abstract
Elevated urine bis(monoacylglycerol)phosphate (BMP) levels have been found in gain-of-kinase function LRRK2 G2019S mutation carriers. Here, we have expanded urine BMP analysis to other Parkinson’s disease (PD) associated mutations and found them to be consistently elevated in carriers of LRRK2 G2019S and R1441G/C as well as VPS35 D620N mutations. Urine BMP levels are promising biomarkers for patient stratification and potentially target engagement in clinical trials of emerging targeted PD therapies.
Original language | English |
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Article number | 52 |
Number of pages | 4 |
Journal | NPJ Parkinson's disease |
Volume | 9 |
DOIs | |
Publication status | Published - 4 Apr 2023 |
Keywords
- Parkinson's disease
- Translational research
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
- Cellular and Molecular Neuroscience
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Dive into the research topics of 'Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease'. Together they form a unique fingerprint.Projects
- 2 Finished
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Differential LRRK2 Dependent Rab Phosphorylation Signatures in Peripheral Blood and Urine in Idiopathic and Monogenetic PD
Alessi, D. (Investigator) & Sammler, E. (Investigator)
1/06/21 → 31/07/24
Project: Research
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Bench-to-Bedside Parkinson's Disease Research: Biomarkers in LRRK2 (NHS Research Scotland (NRS) and Scottish Universities Scottish Senior Clinical Academic Fellowship Scheme)
Sammler, E. (Investigator)
7/01/19 → 30/06/24
Project: Research