Drosophila neuroblasts retain the daughter centrosome

Jens Januschke, Salud Llamazares, Jose Reina, Cayetano Gonzalez (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    127 Citations (Scopus)

    Abstract

    During asymmetric mitosis, both in male Drosophila germline stem cells and in mouse embryo neural progenitors, the mother centrosome is retained by the self-renewed cell; hence suggesting that mother centrosome inheritance might contribute to stemness. We test this hypothesis in Drosophila neuroblasts (NBs) tracing photo converted centrioles and a daughter-centriole-specific marker generated by cloning the Drosophila homologue of human Centrobin. Here we show that upon asymmetric mitosis, the mother centrosome is inherited by the differentiating daughter cell. Our results demonstrate maturation-dependent centrosome fate in Drosophila NBs and that the stemness properties of these cells are not linked to mother centrosome inheritance.
    Original languageEnglish
    Article number243
    JournalNature Communications
    Volume2
    DOIs
    Publication statusPublished - 15 Mar 2011

    Keywords

    • Drosophila melanogaster
    • Centrosome
    • Stem cells

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