Emergent cell and tissue dynamics from subcellular modeling of active biomechanical processes

S. A. Sandersius, C. J. Weijer, T. J. Newman

    Research output: Contribution to journalArticle

    42 Citations (Scopus)

    Abstract

    Cells and the tissues they form are not passive material bodies. Cells change their behavior in response to external biochemical and biomechanical cues. Behavioral changes, such as morphological deformation, proliferation and migration, are striking in many multicellular processes such as morphogenesis, wound healing and cancer progression. Cell-based modeling of these phenomena requires algorithms that can capture active cell behavior and their emergent tissue-level phenotypes. In this paper, we report on extensions of the subcellular element model to model active biomechanical subcellular processes. These processes lead to emergent cell and tissue level phenotypes at larger scales, including (i) adaptive shape deformations in cells responding to slow stretching, (ii) viscous flow of embryonic tissues, and (iii) streaming patterns of chemotactic cells in epithelial-like sheets. In each case, we connect our simulation results to recent experiments.

    Original languageEnglish
    Article number045007
    Number of pages14
    JournalPhysical Biology
    Volume8
    Issue number4
    DOIs
    Publication statusPublished - Aug 2011

    Keywords

    • Primitive streak form
    • Living cell
    • Dictyostelium-discoideum
    • Smooth muscle
    • Migration
    • Morphogenesis
    • Regeneration
    • Mechanics
    • Responses
    • Movement

    Cite this

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    title = "Emergent cell and tissue dynamics from subcellular modeling of active biomechanical processes",
    abstract = "Cells and the tissues they form are not passive material bodies. Cells change their behavior in response to external biochemical and biomechanical cues. Behavioral changes, such as morphological deformation, proliferation and migration, are striking in many multicellular processes such as morphogenesis, wound healing and cancer progression. Cell-based modeling of these phenomena requires algorithms that can capture active cell behavior and their emergent tissue-level phenotypes. In this paper, we report on extensions of the subcellular element model to model active biomechanical subcellular processes. These processes lead to emergent cell and tissue level phenotypes at larger scales, including (i) adaptive shape deformations in cells responding to slow stretching, (ii) viscous flow of embryonic tissues, and (iii) streaming patterns of chemotactic cells in epithelial-like sheets. In each case, we connect our simulation results to recent experiments.",
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    Emergent cell and tissue dynamics from subcellular modeling of active biomechanical processes. / Sandersius, S. A.; Weijer, C. J.; Newman, T. J.

    In: Physical Biology, Vol. 8, No. 4, 045007, 08.2011.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Emergent cell and tissue dynamics from subcellular modeling of active biomechanical processes

    AU - Sandersius, S. A.

    AU - Weijer, C. J.

    AU - Newman, T. J.

    PY - 2011/8

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    AB - Cells and the tissues they form are not passive material bodies. Cells change their behavior in response to external biochemical and biomechanical cues. Behavioral changes, such as morphological deformation, proliferation and migration, are striking in many multicellular processes such as morphogenesis, wound healing and cancer progression. Cell-based modeling of these phenomena requires algorithms that can capture active cell behavior and their emergent tissue-level phenotypes. In this paper, we report on extensions of the subcellular element model to model active biomechanical subcellular processes. These processes lead to emergent cell and tissue level phenotypes at larger scales, including (i) adaptive shape deformations in cells responding to slow stretching, (ii) viscous flow of embryonic tissues, and (iii) streaming patterns of chemotactic cells in epithelial-like sheets. In each case, we connect our simulation results to recent experiments.

    KW - Primitive streak form

    KW - Living cell

    KW - Dictyostelium-discoideum

    KW - Smooth muscle

    KW - Migration

    KW - Morphogenesis

    KW - Regeneration

    KW - Mechanics

    KW - Responses

    KW - Movement

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    DO - 10.1088/1478-3975/8/4/045007

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