Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS

Amy Alexander, Andrew J. Irving, Jenni Harvey (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    19 Citations (Scopus)
    113 Downloads (Pure)

    Abstract

    Estrogens play a key role in regulating reproductive and neuroendocrine function by activating classical nuclear steroid receptors that act as ligand gated transcription factors. However evidence is growing that estrogens also promote rapid non-genomic responses via activation of membrane-associated estrogen receptors. The G protein-coupled estrogen receptor (GPER1; also known as GPR30) has been identified as one of the main estrogen-sensitive receptors responsible for the rapid non-genomic actions of estrogen. In recent years, our understanding of the CNS actions of GPER1s has significantly increased following the development of selective pharmacological tools and via the use of transgenic technologies to knockout GPER1 in mice. Here we review recent advances that have been made to uncover the role of GPER1s in the CNS.

    Original languageEnglish
    Pages (from-to)652-660
    Number of pages9
    JournalNeuropharmacology
    Volume113
    Issue numberPart B
    Early online date5 Jul 2016
    DOIs
    Publication statusPublished - Feb 2017

    Fingerprint

    Estrogen Receptors
    Estrogens
    Steroid Receptors
    Cytoplasmic and Nuclear Receptors
    G-Protein-Coupled Receptors
    Transcription Factors
    Pharmacology
    Ligands
    Technology
    Membranes

    Cite this

    Alexander, Amy ; Irving, Andrew J. ; Harvey, Jenni. / Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS. In: Neuropharmacology. 2017 ; Vol. 113, No. Part B. pp. 652-660.
    @article{6a5320a0dc894839a8c54e1055e5af43,
    title = "Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS",
    abstract = "Estrogens play a key role in regulating reproductive and neuroendocrine function by activating classical nuclear steroid receptors that act as ligand gated transcription factors. However evidence is growing that estrogens also promote rapid non-genomic responses via activation of membrane-associated estrogen receptors. The G protein-coupled estrogen receptor (GPER1; also known as GPR30) has been identified as one of the main estrogen-sensitive receptors responsible for the rapid non-genomic actions of estrogen. In recent years, our understanding of the CNS actions of GPER1s has significantly increased following the development of selective pharmacological tools and via the use of transgenic technologies to knockout GPER1 in mice. Here we review recent advances that have been made to uncover the role of GPER1s in the CNS.",
    author = "Amy Alexander and Irving, {Andrew J.} and Jenni Harvey",
    note = "The Anonymous Trust and Cunningham Trust",
    year = "2017",
    month = "2",
    doi = "10.1016/j.neuropharm.2016.07.003",
    language = "English",
    volume = "113",
    pages = "652--660",
    journal = "Neuropharmacology",
    issn = "0028-3908",
    publisher = "Elsevier",
    number = "Part B",

    }

    Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS. / Alexander, Amy; Irving, Andrew J.; Harvey, Jenni (Lead / Corresponding author).

    In: Neuropharmacology, Vol. 113, No. Part B, 02.2017, p. 652-660.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS

    AU - Alexander, Amy

    AU - Irving, Andrew J.

    AU - Harvey, Jenni

    N1 - The Anonymous Trust and Cunningham Trust

    PY - 2017/2

    Y1 - 2017/2

    N2 - Estrogens play a key role in regulating reproductive and neuroendocrine function by activating classical nuclear steroid receptors that act as ligand gated transcription factors. However evidence is growing that estrogens also promote rapid non-genomic responses via activation of membrane-associated estrogen receptors. The G protein-coupled estrogen receptor (GPER1; also known as GPR30) has been identified as one of the main estrogen-sensitive receptors responsible for the rapid non-genomic actions of estrogen. In recent years, our understanding of the CNS actions of GPER1s has significantly increased following the development of selective pharmacological tools and via the use of transgenic technologies to knockout GPER1 in mice. Here we review recent advances that have been made to uncover the role of GPER1s in the CNS.

    AB - Estrogens play a key role in regulating reproductive and neuroendocrine function by activating classical nuclear steroid receptors that act as ligand gated transcription factors. However evidence is growing that estrogens also promote rapid non-genomic responses via activation of membrane-associated estrogen receptors. The G protein-coupled estrogen receptor (GPER1; also known as GPR30) has been identified as one of the main estrogen-sensitive receptors responsible for the rapid non-genomic actions of estrogen. In recent years, our understanding of the CNS actions of GPER1s has significantly increased following the development of selective pharmacological tools and via the use of transgenic technologies to knockout GPER1 in mice. Here we review recent advances that have been made to uncover the role of GPER1s in the CNS.

    U2 - 10.1016/j.neuropharm.2016.07.003

    DO - 10.1016/j.neuropharm.2016.07.003

    M3 - Article

    VL - 113

    SP - 652

    EP - 660

    JO - Neuropharmacology

    JF - Neuropharmacology

    SN - 0028-3908

    IS - Part B

    ER -