Emerging roles of pseudokinases

Jérôme Boudeau, Diego Miranda-Saavedra, Geoffrey J. Barton, Dario R. Alessi (Lead / Corresponding author)

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    365 Citations (Scopus)

    Abstract

    Kinases control virtually all aspects of biology. Forty-eight human proteins have a kinase-like domain that lacks at least one of the conserved catalytic residues; these proteins are therefore predicted to be inactive and have been termed pseudokinases. Here, we describe exciting work suggesting that pseudokinases, despite lacking the ability to phosphorylate substrates, are still pivotal in regulating diverse cellular processes. We review evidence that the pseudokinase STRAD controls the function of the tumour suppressor kinase LKB1 and that a single amino acid substitution within the pseudokinase domain of the tyrosine kinase JAK2 leads to several malignant myeloproliferative disorders. We also discuss the emerging functions of other pseudokinases, including HER3 (also called ErbB3), EphB6, CCK4 (also called PTK7), KSR, Trb3, GCN2, TRRAP, ILK and CASK.

    Original languageEnglish
    Pages (from-to)443-452
    Number of pages10
    JournalTrends in Cell Biology
    Volume16
    Issue number9
    Early online date1 Aug 2006
    DOIs
    Publication statusPublished - Sep 2006

    Keywords

    • Adaptor proteins, Vesicular Transport
    • Animals
    • Gene expression regulation
    • Humans
    • Janus kinase 2
    • Mice
    • Mutation
    • Myeloproliferative disorders
    • Protein-serine-threonine kinases
    • Protein-tyrosine kinases
    • Proto-oncogene proteins
    • Signal transduction

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