Emerging roles of the mitogen and stress activated kinases MSK1 and MSK2

Kathleen M. S. E. Reyskens; J. Simon C. Arthur

doi:10.3389/fcell.2016.00056

Emerging roles of the mitogen and stress activated kinases MSK1 and MSK2

Kathleen M. S. E. Reyskens, J. Simon C. Arthur (Lead / Corresponding author)

Cell Signalling and Immunology

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Abstract

Mitogen- and stress-activated kinases (MSK) 1 and 2 are nuclear proteins activated downstream of the ERK1/2 or p38 MAPK pathways. MSKs phosphorylate multiple substrates, including CREB and Histone H3, and their major role is the regulation of specific subsets of Immediate Early genes (IEG). While MSKs are expressed in multiple tissues, their levels are high in immune and neuronal cells and it is in these systems most is known about their function. In immunity, MSKs have predominantly anti-inflammatory roles and help regulate production of the anti-inflammatory cytokine IL-10. In the CNS they are implicated in neuronal proliferation and synaptic plasticity. In this review we will focus on recent advances in understanding the roles of MSKs in the innate immune system and neuronal function.

Original language	English
Article number	56
Number of pages	8
Journal	Frontiers in Cell and Developmental Biology
Volume	4
DOIs	https://doi.org/10.3389/fcell.2016.00056
Publication status	Published - 10 Jun 2016

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10.3389/fcell.2016.00056Licence: CC BY

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© 2016 Reyskens and Arthur. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Cite this

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Emerging roles of the mitogen and stress activated kinases MSK1 and MSK2

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