Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

TY - JOUR

T1 - Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

AU - Munday, Jane C.

AU - Eze, Anthonius A

AU - Baker, Nicola

AU - Glover, Lucy

AU - Clucas, Caroline

AU - Andrés, David Aguinaga

AU - Natto, Manal J

AU - Teka, Ibrahim A

AU - McDonald, Jennifer

AU - Lee, Rebecca S

AU - Graf, Fabrice E

AU - Ludin, Philipp

AU - Burchmore, Richard J S

AU - Turner, C Michael R.

AU - Tait, Andy

AU - MacLeod, Annette

AU - Mäser, Pascal

AU - Barrett, Michael P.

AU - Horn, David

AU - De Koning, Harry P.

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T. brucei aquaglyceroporin 2 (TbAQP2) caused melarsoprol/pentamidine cross-resistance (MPXR) in these parasites and the current study aims to delineate the mechanism by which this occurs.

AB - Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T. brucei aquaglyceroporin 2 (TbAQP2) caused melarsoprol/pentamidine cross-resistance (MPXR) in these parasites and the current study aims to delineate the mechanism by which this occurs.

KW - drug transport

KW - protozoan

KW - parasite

KW - resistance mutation

KW - aquaporin

U2 - 10.1093/jac/dkt442

DO - 10.1093/jac/dkt442

M3 - Article

C2 - 24235095

SN - 0305-7453

VL - 69

SP - 651

EP - 663

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 3

ER -