Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

Jane C. Munday, Anthonius A Eze, Nicola Baker, Lucy Glover, Caroline Clucas, David Aguinaga Andrés, Manal J Natto, Ibrahim A Teka, Jennifer McDonald, Rebecca S Lee, Fabrice E Graf, Philipp Ludin, Richard J S Burchmore, C Michael R. Turner, Andy Tait, Annette MacLeod, Pascal Mäser, Michael P. Barrett, David Horn, Harry P. De Koning (Lead / Corresponding author)

Biological Chemistry and Drug Discovery

Research output: Contribution to journal › Article › peer-review

106 Citations (Scopus)

2 results

Finished
Melarsoprol-Pentamidine Cross Resistance in African Trypanosomes.
Horn, D. (Investigator)
Medical Research Council
28/10/13 → 27/10/16
Project: Research
High-Throughput Decoding of Virulence Mechanisms in African Trypanosomes (Senior Investigator Award)
Horn, D. (Investigator)
1/09/13 → 29/02/20
Project: Research

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

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Melarsoprol-Pentamidine Cross Resistance in African Trypanosomes.

High-Throughput Decoding of Virulence Mechanisms in African Trypanosomes (Senior Investigator Award)