End-point selection to determine the airway-systemic ratio of inhaled corticosteroids in asthma

Brian Lipworth; Rory Chan; Chris Rui Wen Kuo

doi:10.1111/bcp.14633

End-point selection to determine the airway-systemic ratio of inhaled corticosteroids in asthma

Brian Lipworth (Lead / Corresponding author), Rory Chan, Chris Rui Wen Kuo

Molecular and Clinical Medicine

Research output: Contribution to journal › Letter › peer-review

1 Citation (Scopus)

Abstract

The use of adenosine monophosphate challenge and basal cortisol as short-term surrogate end points of airway-systemic effects of inhaled corticosteroids in asthma is not suitable to properly determine the clinically relevant long-term therapeutic index.

Original language	English
Pages (from-to)	2401-2402
Number of pages	2
Journal	British Journal of Clinical Pharmacology
Volume	87
Issue number	5
Early online date	23 Nov 2020
DOIs	https://doi.org/10.1111/bcp.14633
Publication status	Published - May 2021

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1111/bcp.14633

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title = "End-point selection to determine the airway-systemic ratio of inhaled corticosteroids in asthma",

abstract = "The use of adenosine monophosphate challenge and basal cortisol as short-term surrogate end points of airway-systemic effects of inhaled corticosteroids in asthma is not suitable to properly determine the clinically relevant long-term therapeutic index.",

author = "Brian Lipworth and Rory Chan and Kuo, {Chris Rui Wen}",

year = "2021",

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AU - Chan, Rory

AU - Kuo, Chris Rui Wen

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N2 - The use of adenosine monophosphate challenge and basal cortisol as short-term surrogate end points of airway-systemic effects of inhaled corticosteroids in asthma is not suitable to properly determine the clinically relevant long-term therapeutic index.

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U2 - 10.1111/bcp.14633

DO - 10.1111/bcp.14633

M3 - Letter

C2 - 33230858

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JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 5

ER -

End-point selection to determine the airway-systemic ratio of inhaled corticosteroids in asthma

Abstract

ASJC Scopus subject areas

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