End-point selection to determine the airway-systemic ratio of inhaled corticosteroids in asthma

Brian Lipworth; Rory Chan; Chris Rui Wen Kuo

doi:10.1111/bcp.14633

End-point selection to determine the airway-systemic ratio of inhaled corticosteroids in asthma

Brian Lipworth (Lead / Corresponding author), Rory Chan, Chris Rui Wen Kuo

Research output: Contribution to journal › Letter › peer-review

2 Citations (Scopus)

Abstract

The use of adenosine monophosphate challenge and basal cortisol as short-term surrogate end points of airway-systemic effects of inhaled corticosteroids in asthma is not suitable to properly determine the clinically relevant long-term therapeutic index.

Original language	English
Pages (from-to)	2401-2402
Number of pages	2
Journal	British Journal of Clinical Pharmacology
Volume	87
Issue number	5
Early online date	23 Nov 2020
DOIs	https://doi.org/10.1111/bcp.14633
Publication status	Published - May 2021

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1111/bcp.14633

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title = "End-point selection to determine the airway-systemic ratio of inhaled corticosteroids in asthma",

abstract = "The use of adenosine monophosphate challenge and basal cortisol as short-term surrogate end points of airway-systemic effects of inhaled corticosteroids in asthma is not suitable to properly determine the clinically relevant long-term therapeutic index.",

author = "Brian Lipworth and Rory Chan and Kuo, \{Chris Rui Wen\}",

year = "2021",

month = may,

doi = "10.1111/bcp.14633",

language = "English",

volume = "87",

pages = "2401--2402",

journal = "British Journal of Clinical Pharmacology",

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T1 - End-point selection to determine the airway-systemic ratio of inhaled corticosteroids in asthma

AU - Lipworth, Brian

AU - Chan, Rory

AU - Kuo, Chris Rui Wen

PY - 2021/5

Y1 - 2021/5

N2 - The use of adenosine monophosphate challenge and basal cortisol as short-term surrogate end points of airway-systemic effects of inhaled corticosteroids in asthma is not suitable to properly determine the clinically relevant long-term therapeutic index.

AB - The use of adenosine monophosphate challenge and basal cortisol as short-term surrogate end points of airway-systemic effects of inhaled corticosteroids in asthma is not suitable to properly determine the clinically relevant long-term therapeutic index.

UR - https://www.scopus.com/pages/publications/85096743677

U2 - 10.1111/bcp.14633

DO - 10.1111/bcp.14633

M3 - Letter

C2 - 33230858

SN - 0306-5251

VL - 87

SP - 2401

EP - 2402

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 5

ER -

End-point selection to determine the airway-systemic ratio of inhaled corticosteroids in asthma

Abstract

ASJC Scopus subject areas

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