EndoCompass project: research roadmap for diabetes, obesity, and metabolism

Chantal Mathieu; Manuela Meireles; Uberto Pagotto; Martin Wabitsch; Indraneel Banerjee; Alberto Bartolomé; Tadej Battelino; Julia Beck; Francesco Chiarelli; Diva D. De Leon; Klemen Dovč; Marwan El Ghoch; Alfonso Galderisi; Evelien Gevers; Pieter Gillard; Belma Haliloglu; Henrike Hoermann; Boris Mankovsky; Jonathan Mertens; Klaus Mohnike; Richard Oram; Tai Pasquini; Ewan Pearson; Thomas R. Pieber; Snezana Polovina; Julie Raskin; Marcia Roeper; Lisa Ruck; Maria Salomon Estebanez; Tsvetalina Tankova; Paul Thornton; Elisabeth F.C. Van Rossum; Rade Vukovic; Chris Worth; Agnieszka Zachurzok

doi:10.1093/ejendo/lvaf065

EndoCompass project: research roadmap for diabetes, obesity, and metabolism

Chantal Mathieu
, Manuela Meireles
, Uberto Pagotto
, Martin Wabitsch (Lead / Corresponding author)
, Indraneel Banerjee
, Alberto Bartolomé
, Tadej Battelino
, Julia Beck
, Francesco Chiarelli
, Diva D. De Leon
, Klemen Dovč
, Marwan El Ghoch
, Alfonso Galderisi
, Evelien Gevers
, Pieter Gillard
, Belma Haliloglu
, Henrike Hoermann
, Boris Mankovsky
, Jonathan Mertens
, Klaus Mohnike

Richard Oram, Tai Pasquini, Ewan Pearson, Thomas R. Pieber, Snezana Polovina, Julie Raskin, Marcia Roeper, Lisa Ruck, Maria Salomon Estebanez, Tsvetalina Tankova, Paul Thornton, Elisabeth F.C. Van Rossum, Rade Vukovic, Chris Worth, Agnieszka Zachurzok

Diabetes Endocrinology and Reproductive Biology

Research output: Contribution to journal › Review article › peer-review

Abstract

Background: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project—a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.

Methods: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.

Results: Research priorities include: genetic/epigenetic factors, brain–periphery communication, and environmental influences. Key therapeutic areas include innovative approaches for monogenic disorders, incretin mimetics, dual receptor agonists, microbiome analysis, and improved behavioural interventions. For type 1 diabetes, priorities focus on early detection, insulin delivery systems, and disease-modifying therapies.

Conclusions: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into diabetes and obesity pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of metabolic disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

Original language	English
Pages (from-to)	ii47-ii71
Number of pages	25
Journal	European Journal of Endocrinology
Volume	193
DOIs	https://doi.org/10.1093/ejendo/lvaf065
Publication status	Published - 17 Oct 2025

Keywords

diabetes
EndoCompass
funding
obesity
roadmap

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ejendo/lvaf065Licence: CC BY

Final published versionFinal published version, 1.33 MBLicence: CC BY

Cite this

Mathieu, C., Meireles, M., Pagotto, U., Wabitsch, M., Banerjee, I., Bartolomé, A., Battelino, T., Beck, J., Chiarelli, F., De Leon, D. D., Dovč, K., El Ghoch, M., Galderisi, A., Gevers, E., Gillard, P., Haliloglu, B., Hoermann, H., Mankovsky, B., Mertens, J., ... Zachurzok, A. (2025). EndoCompass project: research roadmap for diabetes, obesity, and metabolism. European Journal of Endocrinology, 193, ii47-ii71. https://doi.org/10.1093/ejendo/lvaf065

@article{2a5d360f19c145cda846413fa7577af0,

title = "EndoCompass project: research roadmap for diabetes, obesity, and metabolism",

abstract = "Background: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project—a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.Methods: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.Results: Research priorities include: genetic/epigenetic factors, brain–periphery communication, and environmental influences. Key therapeutic areas include innovative approaches for monogenic disorders, incretin mimetics, dual receptor agonists, microbiome analysis, and improved behavioural interventions. For type 1 diabetes, priorities focus on early detection, insulin delivery systems, and disease-modifying therapies.Conclusions: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into diabetes and obesity pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of metabolic disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.",

keywords = "diabetes, EndoCompass, funding, obesity, roadmap",

author = "Chantal Mathieu and Manuela Meireles and Uberto Pagotto and Martin Wabitsch and Indraneel Banerjee and Alberto Bartolom{\'e} and Tadej Battelino and Julia Beck and Francesco Chiarelli and \{De Leon\}, \{Diva D.\} and Klemen Dov{\v c} and \{El Ghoch\}, Marwan and Alfonso Galderisi and Evelien Gevers and Pieter Gillard and Belma Haliloglu and Henrike Hoermann and Boris Mankovsky and Jonathan Mertens and Klaus Mohnike and Richard Oram and Tai Pasquini and Ewan Pearson and Pieber, \{Thomas R.\} and Snezana Polovina and Julie Raskin and Marcia Roeper and Lisa Ruck and \{Salomon Estebanez\}, Maria and Tsvetalina Tankova and Paul Thornton and \{Van Rossum\}, \{Elisabeth F.C.\} and Rade Vukovic and Chris Worth and Agnieszka Zachurzok",

note = "Copyright: {\textcopyright} The Author(s) 2025. Published by Oxford University Press on behalf of European Society of Endocrinology.",

year = "2025",

month = oct,

day = "17",

doi = "10.1093/ejendo/lvaf065",

language = "English",

volume = "193",

pages = "ii47--ii71",

journal = "European Journal of Endocrinology",

issn = "0804-4643",

publisher = "Oxford University Press",

}

Mathieu, C, Meireles, M, Pagotto, U, Wabitsch, M, Banerjee, I, Bartolomé, A, Battelino, T, Beck, J, Chiarelli, F, De Leon, DD, Dovč, K, El Ghoch, M, Galderisi, A, Gevers, E, Gillard, P, Haliloglu, B, Hoermann, H, Mankovsky, B, Mertens, J, Mohnike, K, Oram, R, Pasquini, T, Pearson, E, Pieber, TR, Polovina, S, Raskin, J, Roeper, M, Ruck, L, Salomon Estebanez, M, Tankova, T, Thornton, P, Van Rossum, EFC, Vukovic, R, Worth, C & Zachurzok, A 2025, 'EndoCompass project: research roadmap for diabetes, obesity, and metabolism', European Journal of Endocrinology, vol. 193, pp. ii47-ii71. https://doi.org/10.1093/ejendo/lvaf065

TY - JOUR

T1 - EndoCompass project

T2 - research roadmap for diabetes, obesity, and metabolism

AU - Mathieu, Chantal

AU - Meireles, Manuela

AU - Pagotto, Uberto

AU - Wabitsch, Martin

AU - Banerjee, Indraneel

AU - Bartolomé, Alberto

AU - Battelino, Tadej

AU - Beck, Julia

AU - Chiarelli, Francesco

AU - De Leon, Diva D.

AU - Dovč, Klemen

AU - El Ghoch, Marwan

AU - Galderisi, Alfonso

AU - Gevers, Evelien

AU - Gillard, Pieter

AU - Haliloglu, Belma

AU - Hoermann, Henrike

AU - Mankovsky, Boris

AU - Mertens, Jonathan

AU - Mohnike, Klaus

AU - Oram, Richard

AU - Pasquini, Tai

AU - Pearson, Ewan

AU - Pieber, Thomas R.

AU - Polovina, Snezana

AU - Raskin, Julie

AU - Roeper, Marcia

AU - Ruck, Lisa

AU - Salomon Estebanez, Maria

AU - Tankova, Tsvetalina

AU - Thornton, Paul

AU - Van Rossum, Elisabeth F.C.

AU - Vukovic, Rade

AU - Worth, Chris

AU - Zachurzok, Agnieszka

PY - 2025/10/17

Y1 - 2025/10/17

N2 - Background: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project—a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.Methods: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.Results: Research priorities include: genetic/epigenetic factors, brain–periphery communication, and environmental influences. Key therapeutic areas include innovative approaches for monogenic disorders, incretin mimetics, dual receptor agonists, microbiome analysis, and improved behavioural interventions. For type 1 diabetes, priorities focus on early detection, insulin delivery systems, and disease-modifying therapies.Conclusions: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into diabetes and obesity pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of metabolic disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

AB - Background: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project—a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.Methods: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.Results: Research priorities include: genetic/epigenetic factors, brain–periphery communication, and environmental influences. Key therapeutic areas include innovative approaches for monogenic disorders, incretin mimetics, dual receptor agonists, microbiome analysis, and improved behavioural interventions. For type 1 diabetes, priorities focus on early detection, insulin delivery systems, and disease-modifying therapies.Conclusions: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into diabetes and obesity pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of metabolic disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

KW - diabetes

KW - EndoCompass

KW - funding

KW - obesity

KW - roadmap

UR - https://www.scopus.com/pages/publications/105019114382

U2 - 10.1093/ejendo/lvaf065

DO - 10.1093/ejendo/lvaf065

M3 - Review article

C2 - 41104472

AN - SCOPUS:105019114382

SN - 0804-4643

VL - 193

SP - ii47-ii71

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

ER -

EndoCompass project: research roadmap for diabetes, obesity, and metabolism

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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