Endoderm contributes to endocardial composition during cardiogenesis

Yan Li, Xiaoyu Wang, Zhenglai Ma, Manli Chuai, Andrea Münsterberg, Kenneth KaHo Lee, Xuesong Yang (Lead / Corresponding author)

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    Abstract

    Heart formation commences from a single heart tube, which fuses from bilateral primordial heart fields. The developing heart tube is composed of outer-layer myocardial cells and inner-layer endocardial cells. Several distinct populations of precardiac cells contribute to cardiac morphogenesis. However, it still remains not very clear about the lineage of endocardium at gastrulation stage. Thereby, this study focused on ascertaining the correlation between the hypoblast in gastrulation and endocardium during cardiogenesis. Firstly, the fusing heart tube morphologically is closed to endoderm-derived pharynx floor, implying the possibility that pharynx floor might be wrapped into the formation of endoderm. Secondly, HNK1 is expressed in hypoblast strongly at gastrula stage and subsequently appeared in endocardium of cardiogenesis. Moreover, fate map data displayed that DiI labeled hypoblast was also present in endocardium later on. One more evidence is chick-quail chimera of hypoblast transplantation, in which quail-hypoblast derivative could be identified in endocardium of cardiogenesis by QCPN antibody. In sum, our current data suggests that endoderm in gastrula contribute at least partly to the formation of endocardium of cardiogenesis.
    Original languageEnglish
    Pages (from-to)2749-2755
    Number of pages7
    JournalChinese Science Bulletin
    Volume59
    Issue number22
    Early online date20 May 2014
    DOIs
    Publication statusPublished - Aug 2014

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    heart
    pharynx
    quails
    chimerism
    cells
    morphogenesis
    chicks
    antibodies

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    Li, Y., Wang, X., Ma, Z., Chuai, M., Münsterberg, A., Lee, K. K., & Yang, X. (2014). Endoderm contributes to endocardial composition during cardiogenesis. Chinese Science Bulletin, 59(22), 2749-2755. https://doi.org/10.1007/s11434-014-0366-7
    Li, Yan ; Wang, Xiaoyu ; Ma, Zhenglai ; Chuai, Manli ; Münsterberg, Andrea ; Lee, Kenneth KaHo ; Yang, Xuesong. / Endoderm contributes to endocardial composition during cardiogenesis. In: Chinese Science Bulletin. 2014 ; Vol. 59, No. 22. pp. 2749-2755.
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    abstract = "Heart formation commences from a single heart tube, which fuses from bilateral primordial heart fields. The developing heart tube is composed of outer-layer myocardial cells and inner-layer endocardial cells. Several distinct populations of precardiac cells contribute to cardiac morphogenesis. However, it still remains not very clear about the lineage of endocardium at gastrulation stage. Thereby, this study focused on ascertaining the correlation between the hypoblast in gastrulation and endocardium during cardiogenesis. Firstly, the fusing heart tube morphologically is closed to endoderm-derived pharynx floor, implying the possibility that pharynx floor might be wrapped into the formation of endoderm. Secondly, HNK1 is expressed in hypoblast strongly at gastrula stage and subsequently appeared in endocardium of cardiogenesis. Moreover, fate map data displayed that DiI labeled hypoblast was also present in endocardium later on. One more evidence is chick-quail chimera of hypoblast transplantation, in which quail-hypoblast derivative could be identified in endocardium of cardiogenesis by QCPN antibody. In sum, our current data suggests that endoderm in gastrula contribute at least partly to the formation of endocardium of cardiogenesis.",
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    Li, Y, Wang, X, Ma, Z, Chuai, M, Münsterberg, A, Lee, KK & Yang, X 2014, 'Endoderm contributes to endocardial composition during cardiogenesis', Chinese Science Bulletin, vol. 59, no. 22, pp. 2749-2755. https://doi.org/10.1007/s11434-014-0366-7

    Endoderm contributes to endocardial composition during cardiogenesis. / Li, Yan; Wang, Xiaoyu; Ma, Zhenglai; Chuai, Manli; Münsterberg, Andrea; Lee, Kenneth KaHo; Yang, Xuesong (Lead / Corresponding author).

    In: Chinese Science Bulletin, Vol. 59, No. 22, 08.2014, p. 2749-2755.

    Research output: Contribution to journalArticle

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