Endothelial cell-stimulating angiogenesis factor in vitreous from extraretinal neovascularizations

C M Taylor, R D Kissun, A M Schor, D McLeod, A Garner, J B Weiss

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The presence of endothelial cell-stimulating angiogenic factor (ESAF) in diseased human vitreous humour has been established. The molecular mass and chromatographic behavior of this material and its property of activating procollagenase indicate it to be identical to the ESAF isolated from other sources. The biological activity of ESAF from human vitreous was demonstrated by its ability to induce positive responses in the rabbit corneal pocket, and in the chick chorioallantoic membrane and yolk sac membrane tests.

Original languageEnglish
Pages (from-to)2174-8
Number of pages5
JournalInvestigative Ophthalmology & Visual Science
Volume30
Issue number10
Publication statusPublished - Oct 1989

Keywords

  • Angiogenesis Inducing Agents/isolation & purification
  • Animals
  • Cell Division/drug effects
  • Collagenases
  • Endothelium, Vascular/cytology
  • Enzyme Activation/drug effects
  • Enzyme Precursors/metabolism
  • Eye/blood supply
  • Growth Substances/metabolism
  • Humans
  • Microbial Collagenase/metabolism
  • Neovascularization, Pathologic
  • Rabbits
  • Vitrectomy
  • Vitreous Body/metabolism

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