Endothelial cell-stimulating angiogenesis factor in vitreous from extraretinal neovascularizations

C M Taylor; R D Kissun; A M Schor; D McLeod; A Garner; J B Weiss

Endothelial cell-stimulating angiogenesis factor in vitreous from extraretinal neovascularizations

C M Taylor
, R D Kissun
, A M Schor
, D McLeod
, A Garner
, J B Weiss

Research output: Contribution to journal › Article › peer-review

Abstract

The presence of endothelial cell-stimulating angiogenic factor (ESAF) in diseased human vitreous humour has been established. The molecular mass and chromatographic behavior of this material and its property of activating procollagenase indicate it to be identical to the ESAF isolated from other sources. The biological activity of ESAF from human vitreous was demonstrated by its ability to induce positive responses in the rabbit corneal pocket, and in the chick chorioallantoic membrane and yolk sac membrane tests.

Original language	English
Pages (from-to)	2174-8
Number of pages	5
Journal	Investigative Ophthalmology & Visual Science
Volume	30
Issue number	10
Publication status	Published - Oct 1989

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Angiogenesis Inducing Agents/isolation & purification
Animals
Cell Division/drug effects
Collagenases
Endothelium, Vascular/cytology
Enzyme Activation/drug effects
Enzyme Precursors/metabolism
Eye/blood supply
Growth Substances/metabolism
Humans
Microbial Collagenase/metabolism
Neovascularization, Pathologic
Rabbits
Vitrectomy
Vitreous Body/metabolism

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@article{f5cde22573c2494c9a29f05cc1424d00,

title = "Endothelial cell-stimulating angiogenesis factor in vitreous from extraretinal neovascularizations",

abstract = "The presence of endothelial cell-stimulating angiogenic factor (ESAF) in diseased human vitreous humour has been established. The molecular mass and chromatographic behavior of this material and its property of activating procollagenase indicate it to be identical to the ESAF isolated from other sources. The biological activity of ESAF from human vitreous was demonstrated by its ability to induce positive responses in the rabbit corneal pocket, and in the chick chorioallantoic membrane and yolk sac membrane tests.",

keywords = "Angiogenesis Inducing Agents/isolation \& purification, Animals, Cell Division/drug effects, Collagenases, Endothelium, Vascular/cytology, Enzyme Activation/drug effects, Enzyme Precursors/metabolism, Eye/blood supply, Growth Substances/metabolism, Humans, Microbial Collagenase/metabolism, Neovascularization, Pathologic, Rabbits, Vitrectomy, Vitreous Body/metabolism",

author = "Taylor, \{C M\} and Kissun, \{R D\} and Schor, \{A M\} and D McLeod and A Garner and Weiss, \{J B\}",

year = "1989",

month = oct,

language = "English",

volume = "30",

pages = "2174--8",

journal = "Investigative Ophthalmology \& Visual Science",

issn = "0146-0404",

publisher = "Association for Research in Vision and Ophthalmology Inc.",

number = "10",

}

TY - JOUR

T1 - Endothelial cell-stimulating angiogenesis factor in vitreous from extraretinal neovascularizations

AU - Taylor, C M

AU - Kissun, R D

AU - Schor, A M

AU - McLeod, D

AU - Garner, A

AU - Weiss, J B

PY - 1989/10

Y1 - 1989/10

N2 - The presence of endothelial cell-stimulating angiogenic factor (ESAF) in diseased human vitreous humour has been established. The molecular mass and chromatographic behavior of this material and its property of activating procollagenase indicate it to be identical to the ESAF isolated from other sources. The biological activity of ESAF from human vitreous was demonstrated by its ability to induce positive responses in the rabbit corneal pocket, and in the chick chorioallantoic membrane and yolk sac membrane tests.

AB - The presence of endothelial cell-stimulating angiogenic factor (ESAF) in diseased human vitreous humour has been established. The molecular mass and chromatographic behavior of this material and its property of activating procollagenase indicate it to be identical to the ESAF isolated from other sources. The biological activity of ESAF from human vitreous was demonstrated by its ability to induce positive responses in the rabbit corneal pocket, and in the chick chorioallantoic membrane and yolk sac membrane tests.

KW - Angiogenesis Inducing Agents/isolation & purification

KW - Animals

KW - Cell Division/drug effects

KW - Collagenases

KW - Endothelium, Vascular/cytology

KW - Enzyme Activation/drug effects

KW - Enzyme Precursors/metabolism

KW - Eye/blood supply

KW - Growth Substances/metabolism

KW - Humans

KW - Microbial Collagenase/metabolism

KW - Neovascularization, Pathologic

KW - Rabbits

KW - Vitrectomy

KW - Vitreous Body/metabolism

M3 - Article

C2 - 2477343

SN - 0146-0404

VL - 30

SP - 2174

EP - 2178

JO - Investigative Ophthalmology & Visual Science

JF - Investigative Ophthalmology & Visual Science

IS - 10

ER -

Endothelial cell-stimulating angiogenesis factor in vitreous from extraretinal neovascularizations

Abstract

UN SDGs

Keywords

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