Endothelin-1 levels predict 3-year survival in patients who have amputation for critical leg ischaemia

D. J. Newton, F. Khan, M. McLaren, G. Kennedy, J. J. F. Belch

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    Background: Most patients with critical leg ischaemia (CLI) have co-existing coronary heart disease, which is the main cause of their increased mortality rate. The aim of this study was to investigate whether any markers of endothelial function could predict death in these patients. Methods: In a cohort of 39 patients with CLI who were scheduled for lower-limb amputation, blood levels of vascular endothelial growth factor, homocysteine, endothelin (ET) 1, von Willebrand factor and vascular cell adhesion molecule 1 were measured, as well as forearm vascular responses to the endothelium-dependent vasodilator acetylcholine. Results: Levels of ET-1 were significantly higher in patients who subsequently died within 3 years than in those who were still alive (P = 0·002) and Cox proportional hazards regression analysis demonstrated that ET-1 was an independent predictor of all-cause mortality : hazard ratio 3·53 (95 per cent confidence interval (c.i.) 1·29 to 9·70; P = 0·007) and cardiovascular mortality : hazard ratio 4·15 (95 per cent c.i. 1·30 to 13·23); P = 0·014. Conclusion:ET-1 was an independent predictor of death in these patients with CLI. Copyright © 2005 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
    Original languageEnglish
    Pages (from-to)1377-1381
    Number of pages5
    JournalBritish Journal of Surgery
    Volume92
    Issue number11
    DOIs
    Publication statusPublished - Nov 2005

    Fingerprint

    Endothelin-1
    Amputation
    Leg
    Ischemia
    Survival
    Mortality
    Confidence Intervals
    Endothelium-Dependent Relaxing Factors
    Vascular Cell Adhesion Molecule-1
    von Willebrand Factor
    Homocysteine
    Nuclear Family
    Forearm
    Vascular Endothelial Growth Factor A
    Acetylcholine
    Coronary Disease
    Blood Vessels
    Lower Extremity
    Regression Analysis

    Keywords

    • Amputation mortality
    • Endothelin-1 blood
    • Ischemia blood
    • Leg blood supply

    Cite this

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    title = "Endothelin-1 levels predict 3-year survival in patients who have amputation for critical leg ischaemia",
    abstract = "Background: Most patients with critical leg ischaemia (CLI) have co-existing coronary heart disease, which is the main cause of their increased mortality rate. The aim of this study was to investigate whether any markers of endothelial function could predict death in these patients. Methods: In a cohort of 39 patients with CLI who were scheduled for lower-limb amputation, blood levels of vascular endothelial growth factor, homocysteine, endothelin (ET) 1, von Willebrand factor and vascular cell adhesion molecule 1 were measured, as well as forearm vascular responses to the endothelium-dependent vasodilator acetylcholine. Results: Levels of ET-1 were significantly higher in patients who subsequently died within 3 years than in those who were still alive (P = 0·002) and Cox proportional hazards regression analysis demonstrated that ET-1 was an independent predictor of all-cause mortality : hazard ratio 3·53 (95 per cent confidence interval (c.i.) 1·29 to 9·70; P = 0·007) and cardiovascular mortality : hazard ratio 4·15 (95 per cent c.i. 1·30 to 13·23); P = 0·014. Conclusion:ET-1 was an independent predictor of death in these patients with CLI. Copyright {\circledC} 2005 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.",
    keywords = "Amputation mortality, Endothelin-1 blood, Ischemia blood, Leg blood supply",
    author = "Newton, {D. J.} and F. Khan and M. McLaren and G. Kennedy and Belch, {J. J. F.}",
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    Endothelin-1 levels predict 3-year survival in patients who have amputation for critical leg ischaemia. / Newton, D. J.; Khan, F.; McLaren, M.; Kennedy, G.; Belch, J. J. F.

    In: British Journal of Surgery, Vol. 92, No. 11, 11.2005, p. 1377-1381.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Endothelin-1 levels predict 3-year survival in patients who have amputation for critical leg ischaemia

    AU - Newton, D. J.

    AU - Khan, F.

    AU - McLaren, M.

    AU - Kennedy, G.

    AU - Belch, J. J. F.

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    N2 - Background: Most patients with critical leg ischaemia (CLI) have co-existing coronary heart disease, which is the main cause of their increased mortality rate. The aim of this study was to investigate whether any markers of endothelial function could predict death in these patients. Methods: In a cohort of 39 patients with CLI who were scheduled for lower-limb amputation, blood levels of vascular endothelial growth factor, homocysteine, endothelin (ET) 1, von Willebrand factor and vascular cell adhesion molecule 1 were measured, as well as forearm vascular responses to the endothelium-dependent vasodilator acetylcholine. Results: Levels of ET-1 were significantly higher in patients who subsequently died within 3 years than in those who were still alive (P = 0·002) and Cox proportional hazards regression analysis demonstrated that ET-1 was an independent predictor of all-cause mortality : hazard ratio 3·53 (95 per cent confidence interval (c.i.) 1·29 to 9·70; P = 0·007) and cardiovascular mortality : hazard ratio 4·15 (95 per cent c.i. 1·30 to 13·23); P = 0·014. Conclusion:ET-1 was an independent predictor of death in these patients with CLI. Copyright © 2005 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

    AB - Background: Most patients with critical leg ischaemia (CLI) have co-existing coronary heart disease, which is the main cause of their increased mortality rate. The aim of this study was to investigate whether any markers of endothelial function could predict death in these patients. Methods: In a cohort of 39 patients with CLI who were scheduled for lower-limb amputation, blood levels of vascular endothelial growth factor, homocysteine, endothelin (ET) 1, von Willebrand factor and vascular cell adhesion molecule 1 were measured, as well as forearm vascular responses to the endothelium-dependent vasodilator acetylcholine. Results: Levels of ET-1 were significantly higher in patients who subsequently died within 3 years than in those who were still alive (P = 0·002) and Cox proportional hazards regression analysis demonstrated that ET-1 was an independent predictor of all-cause mortality : hazard ratio 3·53 (95 per cent confidence interval (c.i.) 1·29 to 9·70; P = 0·007) and cardiovascular mortality : hazard ratio 4·15 (95 per cent c.i. 1·30 to 13·23); P = 0·014. Conclusion:ET-1 was an independent predictor of death in these patients with CLI. Copyright © 2005 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

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