Engineered biocompatible nanoparticles for in vivo imaging applications

Shu Chen, Lijun Wang, Suzanne L. Duce, Stuart Brown, Stephen Lee, Andreas Melzer, Alfred Cuschieri, Pascal Andre

    Research output: Contribution to journalArticle

    70 Citations (Scopus)

    Abstract

    Iron-platinum alloy nanoparticles (FePt NPs) are extremely promising candidates for the next generation of contrast agents for magnetic resonance (MR) diagnostic imaging and MR-guided interventions, including hyperthermic ablation of solid cancers. FePt has high Curie temperature, saturation magnetic moment, magneto-crystalline anisotropy, and chemical stability. We describe the synthesis and characterization of a family of biocompatible FePt NPs suitable for biomedical applications, showing and discussing that FePt NPs can exhibit low cytotoxicity. The importance of engineering the interface of strongly magnetic NPs using a coating allowing free aqueous permeation is demonstrated to be an essential parameter in the design of new generations of diagnostic and therapeutic MRI contrast agents. We report effective cell internalization of FePt NPs and demonstrate that they can be used for cellular imaging and in vivo MRI applications. This opens the way for several future applications of FePt NPs, including regenerative medicine and stem cell therapy in addition to enhanced MR diagnostic imaging.

    Original languageEnglish
    Pages (from-to)15022-15029
    Number of pages8
    JournalJournal of the American Chemical Society
    Volume132
    Issue number42
    DOIs
    Publication statusPublished - 27 Oct 2010

    Keywords

    • FCT-FEPT Nanoparticles
    • Biofunctional magnetic nanoparticles
    • MRI contrast agents
    • Size-controlled FCC
    • Thermal stability
    • Cellular uptake
    • Quantum dots
    • Tunable size
    • Hela cells
    • Mechanism

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