Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid

Philip Cohen; Michel Goedert

doi:10.1016/S1074-5521(98)90068-0

Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid

Philip Cohen, Michel Goedert

Research output: Contribution to journal › Short survey › peer-review

18 Citations (Scopus)

Abstract

A major goal of signal transduction research is to identify the substrates and roles of the many protein kinases. The task might be simplified by the discovery that the mutation of a single amino acid dramatically alters the nucleotide specificity of protein kinases and their inhibition by a particular class of anti-inflammatory drug.

Original language	English
Pages (from-to)	R161-R164
Journal	Chemistry and Biology
Volume	5
Issue number	7
DOIs	https://doi.org/10.1016/S1074-5521(98)90068-0
Publication status	Published - 1 Jul 1998

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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title = "Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid",

abstract = "A major goal of signal transduction research is to identify the substrates and roles of the many protein kinases. The task might be simplified by the discovery that the mutation of a single amino acid dramatically alters the nucleotide specificity of protein kinases and their inhibition by a particular class of anti-inflammatory drug.",

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AU - Goedert, Michel

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Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid

Abstract

ASJC Scopus subject areas

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