Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid

Philip Cohen, Michel Goedert

    Research output: Contribution to journalShort surveypeer-review

    17 Citations (Scopus)

    Abstract

    A major goal of signal transduction research is to identify the substrates and roles of the many protein kinases. The task might be simplified by the discovery that the mutation of a single amino acid dramatically alters the nucleotide specificity of protein kinases and their inhibition by a particular class of anti-inflammatory drug.

    Original languageEnglish
    Pages (from-to)R161-R164
    JournalChemistry and Biology
    Volume5
    Issue number7
    DOIs
    Publication statusPublished - 1 Jul 1998

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