Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid

Philip Cohen; Michel Goedert

doi:10.1016/S1074-5521(98)90068-0

Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid

Philip Cohen
, Michel Goedert

Research output: Contribution to journal › Short survey › peer-review

18 Citations (Scopus)

Abstract

A major goal of signal transduction research is to identify the substrates and roles of the many protein kinases. The task might be simplified by the discovery that the mutation of a single amino acid dramatically alters the nucleotide specificity of protein kinases and their inhibition by a particular class of anti-inflammatory drug.

Original language	English
Pages (from-to)	R161-R164
Journal	Chemistry and Biology
Volume	5
Issue number	7
DOIs	https://doi.org/10.1016/S1074-5521(98)90068-0
Publication status	Published - 1 Jul 1998

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

Access to Document

10.1016/S1074-5521(98)90068-0Licence: Elsevier User Licence

Cite this

@article{e334d07f3f2343b590490dbf7dd5b7f1,

title = "Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid",

abstract = "A major goal of signal transduction research is to identify the substrates and roles of the many protein kinases. The task might be simplified by the discovery that the mutation of a single amino acid dramatically alters the nucleotide specificity of protein kinases and their inhibition by a particular class of anti-inflammatory drug.",

author = "Philip Cohen and Michel Goedert",

year = "1998",

month = jul,

day = "1",

doi = "10.1016/S1074-5521(98)90068-0",

language = "English",

volume = "5",

pages = "R161--R164",

journal = "Chemistry and Biology",

issn = "1074-5521",

publisher = "Elsevier",

number = "7",

}

TY - JOUR

T1 - Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid

AU - Cohen, Philip

AU - Goedert, Michel

PY - 1998/7/1

Y1 - 1998/7/1

N2 - A major goal of signal transduction research is to identify the substrates and roles of the many protein kinases. The task might be simplified by the discovery that the mutation of a single amino acid dramatically alters the nucleotide specificity of protein kinases and their inhibition by a particular class of anti-inflammatory drug.

AB - A major goal of signal transduction research is to identify the substrates and roles of the many protein kinases. The task might be simplified by the discovery that the mutation of a single amino acid dramatically alters the nucleotide specificity of protein kinases and their inhibition by a particular class of anti-inflammatory drug.

UR - https://www.scopus.com/pages/publications/0032127543

U2 - 10.1016/S1074-5521(98)90068-0

DO - 10.1016/S1074-5521(98)90068-0

M3 - Short survey

AN - SCOPUS:0032127543

SN - 1074-5521

VL - 5

SP - R161-R164

JO - Chemistry and Biology

JF - Chemistry and Biology

IS - 7

ER -

Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this