Enhanced antibacterial and anti-adhesive activities of silver–PTFE nanocomposite coating for urinary catheters

Shuai Zhang, Liyun Wang, Xinjin Liang, Jan Vorstius, Robert Keatch, George Corner, Ghulam Nabi, Fordyce Davidson, Geoffrey Michael Gadd, Qi Zhao (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)
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Catheter associated urinary tract infection (CAUTI) presents a significant health problem worldwide and is associated with increased morbidity and mortality. Herein, a silver-polytetrafluoroethylene (Ag-PTFE) nanocomposite coating for catheters was developed via a facile wet chemistry method. Benefiting from the synergistic effect of Ag and PTFE, the as-prepared Ag-PTFE coated catheter exhibited enhanced antibacterial and anti-adhesive activities against two CAUTI-associated strains: E. coli WT F1693 and S. aureus F1557. Compared to the uncoated commercial silicone catheters and the Ag coated catheters, the Ag-PTFE coated catheters were able to reduce bacterial adhesion by up to 60.3% and 55.2%, respectively. The Ag-PTFE coated catheters also exhibited strong antibiofilm activity, reducing biofilm coverage by up to 97.4% compared with the commercial silicone catheters. In an in vitro bladder model, the Ag-PTFE coated catheter displayed excellent anti-infection efficacy against bacteriuria, extending the lifetime of silicone catheters from a mean of 6 days to over 40 days. The Ag-PTFE coating also showed good biocompatibility with fibroblast cells in culture, making it a prospective strategy to overcome current challenges in CAUTI.
Original languageEnglish
Pages (from-to)2804-2814
Number of pages11
JournalACS Biomaterials Science and Engineering
Issue number6
Early online date2 May 2019
Publication statusPublished - Jun 2019


  • antibacterial
  • coatings
  • infections
  • polytetrafluoroethylene
  • silver
  • urinary catheter

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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