Catheter associated urinary tract infection (CAUTI) presents a significant health problem worldwide and is associated with increased morbidity and mortality. Herein, a silver-polytetrafluoroethylene (Ag-PTFE) nanocomposite coating for catheters was developed via a facile wet chemistry method. Benefiting from the synergistic effect of Ag and PTFE, the as-prepared Ag-PTFE coated catheter exhibited enhanced antibacterial and anti-adhesive activities against two CAUTI-associated strains: E. coli WT F1693 and S. aureus F1557. Compared to the uncoated commercial silicone catheters and the Ag coated catheters, the Ag-PTFE coated catheters were able to reduce bacterial adhesion by up to 60.3% and 55.2%, respectively. The Ag-PTFE coated catheters also exhibited strong antibiofilm activity, reducing biofilm coverage by up to 97.4% compared with the commercial silicone catheters. In an in vitro bladder model, the Ag-PTFE coated catheter displayed excellent anti-infection efficacy against bacteriuria, extending the lifetime of silicone catheters from a mean of 6 days to over 40 days. The Ag-PTFE coating also showed good biocompatibility with fibroblast cells in culture, making it a prospective strategy to overcome current challenges in CAUTI.
- urinary catheter
Zhang, S., Wang, L., Liang, X., Vorstius, J., Keatch, R., Corner, G., Nabi, G., Davidson, F., Gadd, G. M., & Zhao, Q. (2019). Enhanced antibacterial and anti-adhesive activities of silver–PTFE nanocomposite coating for urinary catheters. ACS Biomaterials Science and Engineering, 5(6), 2804-2814. https://doi.org/10.1021/acsbiomaterials.9b00071