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Catheter associated urinary tract infection (CAUTI) presents a significant health problem worldwide and is associated with increased morbidity and mortality. Herein, a silver-polytetrafluoroethylene (Ag-PTFE) nanocomposite coating for catheters was developed via a facile wet chemistry method. Benefiting from the synergistic effect of Ag and PTFE, the as-prepared Ag-PTFE coated catheter exhibited enhanced antibacterial and anti-adhesive activities against two CAUTI-associated strains: E. coli WT F1693 and S. aureus F1557. Compared to the uncoated commercial silicone catheters and the Ag coated catheters, the Ag-PTFE coated catheters were able to reduce bacterial adhesion by up to 60.3% and 55.2%, respectively. The Ag-PTFE coated catheters also exhibited strong antibiofilm activity, reducing biofilm coverage by up to 97.4% compared with the commercial silicone catheters. In an in vitro bladder model, the Ag-PTFE coated catheter displayed excellent anti-infection efficacy against bacteriuria, extending the lifetime of silicone catheters from a mean of 6 days to over 40 days. The Ag-PTFE coating also showed good biocompatibility with fibroblast cells in culture, making it a prospective strategy to overcome current challenges in CAUTI.
|Number of pages||11|
|Journal||ACS Biomaterials Science and Engineering|
|Early online date||2 May 2019|
|Publication status||Published - Jun 2019|
- urinary catheter
ASJC Scopus subject areas
- Biomedical Engineering
FingerprintDive into the research topics of 'Enhanced antibacterial and anti-adhesive activities of silver–PTFE nanocomposite coating for urinary catheters'. Together they form a unique fingerprint.
- 1 Finished
Influence of Surface Properties of New Biomaterials for Catheters on Bacterial Adhesion Urine
Campbell, P., Corner, G., Davidson, F., Keatch, R., Nabi, G., Vorstius, J., Wilcox, K. & Zhao, Q.
Engineering and Physical Sciences Research Council
1/12/16 → 31/10/21
- Imaging Science and Technology - Clinical Professor (Teaching and Research) of Surgical Uro-Oncology