Enhanced antibacterial and anti-adhesive activities of silver–PTFE nanocomposite coating for urinary catheters

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Abstract

Catheter associated urinary tract infection (CAUTI) presents a significant health problem worldwide and is associated with increased morbidity and mortality. Herein, a silver-polytetrafluoroethylene (Ag-PTFE) nanocomposite coating for catheters was developed via a facile wet chemistry method. Benefiting from the synergistic effect of Ag and PTFE, the as-prepared Ag-PTFE coated catheter exhibited enhanced antibacterial and anti-adhesive activities against two CAUTI-associated strains: E. coli WT F1693 and S. aureus F1557. Compared to the uncoated commercial silicone catheters and the Ag coated catheters, the Ag-PTFE coated catheters were able to reduce bacterial adhesion by up to 60.3% and 55.2%, respectively. The Ag-PTFE coated catheters also exhibited strong antibiofilm activity, reducing biofilm coverage by up to 97.4% compared with the commercial silicone catheters. In an in vitro bladder model, the Ag-PTFE coated catheter displayed excellent anti-infection efficacy against bacteriuria, extending the lifetime of silicone catheters from a mean of 6 days to over 40 days. The Ag-PTFE coating also showed good biocompatibility with fibroblast cells in culture, making it a prospective strategy to overcome current challenges in CAUTI.
Original languageEnglish
Pages (from-to)2804-2814
Number of pages11
JournalACS Biomaterials Science and Engineering
Volume5
Issue number6
Early online date2 May 2019
DOIs
Publication statusPublished - Jun 2019

Fingerprint

Nanocomposites
Urinary Catheters
Polytetrafluoroethylene
Adhesives
Catheters
Catheter-Related Infections
Silicones
Urinary Tract Infections
Bacterial Adhesion
Bacteriuria
Biofilms
Silver
Urinary Bladder
Cell Culture Techniques
Fibroblasts
Escherichia coli
Morbidity

Keywords

  • antibacterial
  • coatings
  • infections
  • polytetrafluoroethylene
  • silver
  • urinary catheter

Cite this

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title = "Enhanced antibacterial and anti-adhesive activities of silver–PTFE nanocomposite coating for urinary catheters",
abstract = "Catheter associated urinary tract infection (CAUTI) presents a significant health problem worldwide and is associated with increased morbidity and mortality. Herein, a silver-polytetrafluoroethylene (Ag-PTFE) nanocomposite coating for catheters was developed via a facile wet chemistry method. Benefiting from the synergistic effect of Ag and PTFE, the as-prepared Ag-PTFE coated catheter exhibited enhanced antibacterial and anti-adhesive activities against two CAUTI-associated strains: E. coli WT F1693 and S. aureus F1557. Compared to the uncoated commercial silicone catheters and the Ag coated catheters, the Ag-PTFE coated catheters were able to reduce bacterial adhesion by up to 60.3{\%} and 55.2{\%}, respectively. The Ag-PTFE coated catheters also exhibited strong antibiofilm activity, reducing biofilm coverage by up to 97.4{\%} compared with the commercial silicone catheters. In an in vitro bladder model, the Ag-PTFE coated catheter displayed excellent anti-infection efficacy against bacteriuria, extending the lifetime of silicone catheters from a mean of 6 days to over 40 days. The Ag-PTFE coating also showed good biocompatibility with fibroblast cells in culture, making it a prospective strategy to overcome current challenges in CAUTI.",
keywords = "antibacterial, coatings, infections, polytetrafluoroethylene, silver, urinary catheter",
author = "Shuai Zhang and Liyun Wang and Xinjin Liang and Jan Vorstius and Robert Keatch and George Corner and Ghulam Nabi and Fordyce Davidson and Gadd, {Geoffrey Michael} and Qi Zhao",
note = "This work was supported by the Engineering and Physical Sciences Research Council [EPSRC, EP/P00301X/1]",
year = "2019",
month = "6",
doi = "10.1021/acsbiomaterials.9b00071",
language = "English",
volume = "5",
pages = "2804--2814",
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TY - JOUR

T1 - Enhanced antibacterial and anti-adhesive activities of silver–PTFE nanocomposite coating for urinary catheters

AU - Zhang, Shuai

AU - Wang, Liyun

AU - Liang, Xinjin

AU - Vorstius, Jan

AU - Keatch, Robert

AU - Corner, George

AU - Nabi, Ghulam

AU - Davidson, Fordyce

AU - Gadd, Geoffrey Michael

AU - Zhao, Qi

N1 - This work was supported by the Engineering and Physical Sciences Research Council [EPSRC, EP/P00301X/1]

PY - 2019/6

Y1 - 2019/6

N2 - Catheter associated urinary tract infection (CAUTI) presents a significant health problem worldwide and is associated with increased morbidity and mortality. Herein, a silver-polytetrafluoroethylene (Ag-PTFE) nanocomposite coating for catheters was developed via a facile wet chemistry method. Benefiting from the synergistic effect of Ag and PTFE, the as-prepared Ag-PTFE coated catheter exhibited enhanced antibacterial and anti-adhesive activities against two CAUTI-associated strains: E. coli WT F1693 and S. aureus F1557. Compared to the uncoated commercial silicone catheters and the Ag coated catheters, the Ag-PTFE coated catheters were able to reduce bacterial adhesion by up to 60.3% and 55.2%, respectively. The Ag-PTFE coated catheters also exhibited strong antibiofilm activity, reducing biofilm coverage by up to 97.4% compared with the commercial silicone catheters. In an in vitro bladder model, the Ag-PTFE coated catheter displayed excellent anti-infection efficacy against bacteriuria, extending the lifetime of silicone catheters from a mean of 6 days to over 40 days. The Ag-PTFE coating also showed good biocompatibility with fibroblast cells in culture, making it a prospective strategy to overcome current challenges in CAUTI.

AB - Catheter associated urinary tract infection (CAUTI) presents a significant health problem worldwide and is associated with increased morbidity and mortality. Herein, a silver-polytetrafluoroethylene (Ag-PTFE) nanocomposite coating for catheters was developed via a facile wet chemistry method. Benefiting from the synergistic effect of Ag and PTFE, the as-prepared Ag-PTFE coated catheter exhibited enhanced antibacterial and anti-adhesive activities against two CAUTI-associated strains: E. coli WT F1693 and S. aureus F1557. Compared to the uncoated commercial silicone catheters and the Ag coated catheters, the Ag-PTFE coated catheters were able to reduce bacterial adhesion by up to 60.3% and 55.2%, respectively. The Ag-PTFE coated catheters also exhibited strong antibiofilm activity, reducing biofilm coverage by up to 97.4% compared with the commercial silicone catheters. In an in vitro bladder model, the Ag-PTFE coated catheter displayed excellent anti-infection efficacy against bacteriuria, extending the lifetime of silicone catheters from a mean of 6 days to over 40 days. The Ag-PTFE coating also showed good biocompatibility with fibroblast cells in culture, making it a prospective strategy to overcome current challenges in CAUTI.

KW - antibacterial

KW - coatings

KW - infections

KW - polytetrafluoroethylene

KW - silver

KW - urinary catheter

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U2 - 10.1021/acsbiomaterials.9b00071

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