Enhanced Antibacterial and Antiadhesive Activities of Silver-PTFE Nanocomposite Coating for Urinary Catheters

TY - JOUR

T1 - Enhanced Antibacterial and Antiadhesive Activities of Silver-PTFE Nanocomposite Coating for Urinary Catheters

AU - Zhang, Shuai

AU - Wang, Liyun

AU - Liang, Xinjin

AU - Vorstius, Jan

AU - Keatch, Robert

AU - Corner, George

AU - Nabi, Ghulam

AU - Davidson, Fordyce

AU - Gadd, Geoffrey Michael

AU - Zhao, Qi

N1 - Copyright © 2019 American Chemical Society

PY - 2019

Y1 - 2019

N2 - Catheter-associated urinary tract infection (CAUTI) presents a significant health problem worldwide and is associated with increased morbidity and mortality. Herein, a silver-polytetrafluoroethylene (Ag-PTFE) nanocomposite coating for catheters was developed via a facile wet chemistry method. Benefiting from the synergistic effect of Ag and PTFE, the as-prepared Ag-PTFE-coated catheter exhibited enhanced antibacterial and antiadhesive activities against two CAUTI-associated strains: E. coli WT F1693 and S. aureus F1557. Compared to the uncoated commercial silicone catheters and the Ag-coated catheters, the Ag-PTFE-coated catheters were able to reduce bacterial adhesion by up to 60.3% and 55.2%, respectively. The Ag-PTFE-coated catheters also exhibited strong antibiofilm activity, reducing biofilm coverage by up to 97.4% compared with the commercial silicone catheters. In an in vitro bladder model, the Ag-PTFE-coated catheter displayed excellent anti-infection efficacy against bacteriuria, extending the lifetime of silicone catheters from a mean of 6 days to over 40 days. The Ag-PTFE coating also showed good biocompatibility with fibroblast cells in culture, making it a prospective strategy to overcome current challenges in CAUTI.

AB - Catheter-associated urinary tract infection (CAUTI) presents a significant health problem worldwide and is associated with increased morbidity and mortality. Herein, a silver-polytetrafluoroethylene (Ag-PTFE) nanocomposite coating for catheters was developed via a facile wet chemistry method. Benefiting from the synergistic effect of Ag and PTFE, the as-prepared Ag-PTFE-coated catheter exhibited enhanced antibacterial and antiadhesive activities against two CAUTI-associated strains: E. coli WT F1693 and S. aureus F1557. Compared to the uncoated commercial silicone catheters and the Ag-coated catheters, the Ag-PTFE-coated catheters were able to reduce bacterial adhesion by up to 60.3% and 55.2%, respectively. The Ag-PTFE-coated catheters also exhibited strong antibiofilm activity, reducing biofilm coverage by up to 97.4% compared with the commercial silicone catheters. In an in vitro bladder model, the Ag-PTFE-coated catheter displayed excellent anti-infection efficacy against bacteriuria, extending the lifetime of silicone catheters from a mean of 6 days to over 40 days. The Ag-PTFE coating also showed good biocompatibility with fibroblast cells in culture, making it a prospective strategy to overcome current challenges in CAUTI.

KW - antibacterial

KW - coatings

KW - infections

KW - polytetrafluoroethylene

KW - silver

KW - urinary catheter

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85183529626&origin=resultslist&sort=plf-f&src=s&sid=ec89c8e817c7d054fc46bef1d95ff09b&sot=b&sdt=b&s=TITLE-ABS-KEY%28Enhanced+Antibacterial+and+Antiadhesive+Activities+of+Silver-PTFE+Nanocomposite+Coating+for+Urinary+Catheters%29&sl=124&sessionSearchId=ec89c8e817c7d054fc46bef1d95ff09b&relpos=0

U2 - 10.1021/acsbiomaterials.9b00071

DO - 10.1021/acsbiomaterials.9b00071

M3 - Article

SN - 2373-9878

VL - 5

SP - 2804

EP - 2814

JO - ACS Biomaterials Science and Engineering

JF - ACS Biomaterials Science and Engineering

IS - 6

ER -