Enhanced cell transfection using subwavelength focused optical eigenmode beams [Invited]

Xanthi Tsampoula, Michael Mazilu (Lead / Corresponding author), Tom Vettenburg, Frank Gunn-Moore, Kishan Dholakia

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

We show that superoscillating light fields, created using the method of optical eigenmodes, enable more efficient multiphoton-mediated cell transfection. Chinese hamster ovary cells are transfected with a plasmid and exhibit expression of DsRed-Mito in the mitochondria. We demonstrate an efficiency improvement of 35% compared to the diffraction-limited spot. This opens up new vistas for nanoscale localized cell transfection.

Original languageEnglish
Pages (from-to)42-46
Number of pages5
JournalPhotonics Research
Volume1
Issue number1
DOIs
Publication statusPublished - 1 Jan 2013

Keywords

  • Diffractive optics
  • Laser beam shaping

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