Enhanced deep detection of Raman scattered light by wavefront shaping

Alba M. Paniagua-Diaz; Adrian Ghita; Tom Vettenburg; Nick Stone; Jacopo Bertolotti

doi:10.1364/OE.26.033565

Enhanced deep detection of Raman scattered light by wavefront shaping

Alba M. Paniagua-Diaz, Adrian Ghita, Tom Vettenburg, Nick Stone, Jacopo Bertolotti

Physics

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

152 Downloads (Pure)

Abstract

Light scattering limits the penetration depth of non-invasive Raman spectroscopy in biological media. While safe levels of irradiation may be adequate to analyze superficial tissue, scattering of the pump beam reduces the Raman signal to undetectable levels deeper within the tissue. Here we demonstrate how wavefront shaping techniques can significantly increase the Raman signal at depth, while keeping the total irradiance constant, thus increasing the amount of Raman signal available for detection.

Original language	English
Pages (from-to)	33565-33574
Number of pages	10
Journal	Optics Express
Volume	26
Issue number	26
DOIs	https://doi.org/10.1364/OE.26.033565
Publication status	Published - 24 Dec 2018

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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10.1364/OE.26.033565Licence: CC BY

Final Published VersionFinal published version, 2.73 MBLicence: CC BY

Cite this

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title = "Enhanced deep detection of Raman scattered light by wavefront shaping",

abstract = "Light scattering limits the penetration depth of non-invasive Raman spectroscopy in biological media. While safe levels of irradiation may be adequate to analyze superficial tissue, scattering of the pump beam reduces the Raman signal to undetectable levels deeper within the tissue. Here we demonstrate how wavefront shaping techniques can significantly increase the Raman signal at depth, while keeping the total irradiance constant, thus increasing the amount of Raman signal available for detection.",

author = "Paniagua-Diaz, {Alba M.} and Adrian Ghita and Tom Vettenburg and Nick Stone and Jacopo Bertolotti",

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AU - Ghita, Adrian

AU - Vettenburg, Tom

AU - Stone, Nick

AU - Bertolotti, Jacopo

PY - 2018/12/24

Y1 - 2018/12/24

N2 - Light scattering limits the penetration depth of non-invasive Raman spectroscopy in biological media. While safe levels of irradiation may be adequate to analyze superficial tissue, scattering of the pump beam reduces the Raman signal to undetectable levels deeper within the tissue. Here we demonstrate how wavefront shaping techniques can significantly increase the Raman signal at depth, while keeping the total irradiance constant, thus increasing the amount of Raman signal available for detection.

AB - Light scattering limits the penetration depth of non-invasive Raman spectroscopy in biological media. While safe levels of irradiation may be adequate to analyze superficial tissue, scattering of the pump beam reduces the Raman signal to undetectable levels deeper within the tissue. Here we demonstrate how wavefront shaping techniques can significantly increase the Raman signal at depth, while keeping the total irradiance constant, thus increasing the amount of Raman signal available for detection.

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Enhanced deep detection of Raman scattered light by wavefront shaping

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Vettenburg, Tom

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Enhanced deep detection of Raman scattered light by wavefront shaping

Abstract

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Vettenburg, Tom

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