Enhanced deep detection of Raman scattered light by wavefront shaping

Alba M. Paniagua-Diaz, Adrian Ghita, Tom Vettenburg, Nick Stone, Jacopo Bertolotti

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
89 Downloads (Pure)

Abstract

Light scattering limits the penetration depth of non-invasive Raman spectroscopy in biological media. While safe levels of irradiation may be adequate to analyze superficial tissue, scattering of the pump beam reduces the Raman signal to undetectable levels deeper within the tissue. Here we demonstrate how wavefront shaping techniques can significantly increase the Raman signal at depth, while keeping the total irradiance constant, thus increasing the amount of Raman signal available for detection.

Original languageEnglish
Pages (from-to)33565-33574
Number of pages10
JournalOptics Express
Volume26
Issue number26
DOIs
Publication statusPublished - 24 Dec 2018

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