Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling

Michele West, Robert P. A. Wallin, Stephen Matthews, Henrik G. Svensson, Rossana Zaru, Hans-Gustaf Ljunggren, Alan R. Prescott, Colin Watts

    Research output: Contribution to journalArticlepeer-review

    395 Citations (Scopus)

    Abstract

    Microbial products are sensed through Toll-like receptors (TLRs) and trigger a program of dendritic cell (DC) maturation that enables DCs to activate T cells. Although an accepted hallmark of this response is eventual down-regulation of DC endocytic capacity, we show that TLR ligands first acutely stimulate antigen macropinocytosis, leading to enhanced presentation on class I and class II major histocompatibility complex molecules. Simultaneously, actin-rich podosomes disappear, which suggests a coordinated redeployment of actin to fuel endocytosis. These reciprocal changes are transient and require p38 and extracellular signal–regulated kinase activation. Thus, the DC actin cytoskeleton can be rapidly mobilized in response to innate immune stimuli to enhance antigen capture and presentation.
    Original languageEnglish
    Pages (from-to)1153-1157
    Number of pages5
    JournalScience
    Volume305
    Issue number5687
    DOIs
    Publication statusPublished - 2004

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