Environmental and metabolic sensors that control T cell biology

George Ramsay, Doreen Cantrell (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    28 Citations (Scopus)

    Abstract

    The T lymphocyte response to pathogens is shaped by the microenvironment. Environmental sensors in T cells include the nutrient-sensing serine/threonine kinases, adenosine monophosphate-activated protein kinase and mammalian target of rapamycin complex 1. Other environmental sensors are transcription factors such as hypoxia-inducible factor-1 and the aryl hydrocarbon receptor. The present review explores the molecular basis for the impact of environmental signals on the differentiation of conventional T cell receptor αβ T cells and how the T cell response to immune stimuli can coordinate the T cell response to environmental cues.

    Original languageEnglish
    Article number99
    Number of pages8
    JournalFrontiers in Immunology
    Volume6
    Early online date17 Mar 2015
    DOIs
    Publication statusPublished - 2015

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