Abstract
The T lymphocyte response to pathogens is shaped by the microenvironment. Environmental sensors in T cells include the nutrient-sensing serine/threonine kinases, adenosine monophosphate-activated protein kinase and mammalian target of rapamycin complex 1. Other environmental sensors are transcription factors such as hypoxia-inducible factor-1 and the aryl hydrocarbon receptor. The present review explores the molecular basis for the impact of environmental signals on the differentiation of conventional T cell receptor αβ T cells and how the T cell response to immune stimuli can coordinate the T cell response to environmental cues.
| Original language | English |
|---|---|
| Article number | 99 |
| Number of pages | 8 |
| Journal | Frontiers in Immunology |
| Volume | 6 |
| Early online date | 17 Mar 2015 |
| DOIs | |
| Publication status | Published - 2015 |