Enzymatic inhibitory activity and trypanocidal effects of extracts and compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham.

Margareth B. C. Gallo; Anna Sylvia F. Marques; Paulo C. Vieira; Maria Fatima das G. F. da Silva; Joao B. Fernandes; Marcio Silva; Rafael V. Guido; Glaucius Oliva; Otavio H. Thiemann; Sergio Albuquerque; Alan H. Fairlamb

Enzymatic inhibitory activity and trypanocidal effects of extracts and compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham.

Margareth B. C. Gallo, Anna Sylvia F. Marques, Paulo C. Vieira, Maria Fatima das G. F. da Silva, Joao B. Fernandes, Marcio Silva, Rafael V. Guido, Glaucius Oliva, Otavio H. Thiemann, Sergio Albuquerque, Alan H. Fairlamb

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Hexanic, methanolic, and hydroalcoholic extracts, and 34 isolated compounds from Vitex polygama Cham. (Lamiaceae, formely Verbenaceae) and Siphoneugena densiflora O. Berg (Myrtaceae) were screened for their trypanocidal effects on bloodstream forms of Trypanosoma cruzi and T brucei, as well as for their enzymatic inhibitory activities on glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) and trypanothione reductase (TR) enzymes from T cruzi and adeninephosphoribosyl transferase (APRT) enzyme from Leishmania tarentolae. In general, polar extracts displayed strong effects and some of the tested compounds have shown good results in comparison to positive controls of the bioassays.

Original language	English
Pages (from-to)	371-382
Number of pages	12
Journal	Zeitschrift für Naturforschung C: a Journal of Biosciences
Volume	63
Issue number	5-6
Publication status	Published - 2008

Keywords

myrtaceae
Trypanosoma
Leishmania
PLANT-EXTRACTS
CONSTITUENTS
IDENTIFICATION
METABOLISM
MYRTACEAE
TRYPANOTHIONE
TRYPANOSOMES
FLAVONOIDS
FEATURES

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Gallo, M. B. C., Marques, A. S. F., Vieira, P. C., da Silva, M. F. D. G. F., Fernandes, J. B., Silva, M., Guido, R. V., Oliva, G., Thiemann, O. H., Albuquerque, S., & Fairlamb, A. H. (2008). Enzymatic inhibitory activity and trypanocidal effects of extracts and compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham. Zeitschrift für Naturforschung C: a Journal of Biosciences, 63(5-6), 371-382. http://www.znaturforsch.com/ac/v63c/c63c.htm#No5

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title = "Enzymatic inhibitory activity and trypanocidal effects of extracts and compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham.",

abstract = "Hexanic, methanolic, and hydroalcoholic extracts, and 34 isolated compounds from Vitex polygama Cham. (Lamiaceae, formely Verbenaceae) and Siphoneugena densiflora O. Berg (Myrtaceae) were screened for their trypanocidal effects on bloodstream forms of Trypanosoma cruzi and T brucei, as well as for their enzymatic inhibitory activities on glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) and trypanothione reductase (TR) enzymes from T cruzi and adeninephosphoribosyl transferase (APRT) enzyme from Leishmania tarentolae. In general, polar extracts displayed strong effects and some of the tested compounds have shown good results in comparison to positive controls of the bioassays.",

keywords = "myrtaceae, Trypanosoma, Leishmania, PLANT-EXTRACTS, CONSTITUENTS, IDENTIFICATION, METABOLISM, MYRTACEAE, TRYPANOTHIONE, TRYPANOSOMES, FLAVONOIDS, FEATURES",

author = "Gallo, {Margareth B. C.} and Marques, {Anna Sylvia F.} and Vieira, {Paulo C.} and {da Silva}, {Maria Fatima das G. F.} and Fernandes, {Joao B.} and Marcio Silva and Guido, {Rafael V.} and Glaucius Oliva and Thiemann, {Otavio H.} and Sergio Albuquerque and Fairlamb, {Alan H.}",

year = "2008",

language = "English",

volume = "63",

pages = "371--382",

journal = "Zeitschrift f{\"u}r Naturforschung C: a Journal of Biosciences",

issn = "0939-5075",

publisher = "Verlag der Zeitschrift fur Naturforschung",

number = "5-6",

}

Gallo, MBC, Marques, ASF, Vieira, PC, da Silva, MFDGF, Fernandes, JB, Silva, M, Guido, RV, Oliva, G, Thiemann, OH, Albuquerque, S & Fairlamb, AH 2008, 'Enzymatic inhibitory activity and trypanocidal effects of extracts and compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham.', Zeitschrift für Naturforschung C: a Journal of Biosciences, vol. 63, no. 5-6, pp. 371-382. <http://www.znaturforsch.com/ac/v63c/c63c.htm#No5>

Enzymatic inhibitory activity and trypanocidal effects of extracts and compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham. / Gallo, Margareth B. C.; Marques, Anna Sylvia F.; Vieira, Paulo C. et al.
In: Zeitschrift für Naturforschung C: a Journal of Biosciences, Vol. 63, No. 5-6, 2008, p. 371-382.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Enzymatic inhibitory activity and trypanocidal effects of extracts and compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham.

AU - Gallo, Margareth B. C.

AU - Marques, Anna Sylvia F.

AU - Vieira, Paulo C.

AU - da Silva, Maria Fatima das G. F.

AU - Fernandes, Joao B.

AU - Silva, Marcio

AU - Guido, Rafael V.

AU - Oliva, Glaucius

AU - Thiemann, Otavio H.

AU - Albuquerque, Sergio

AU - Fairlamb, Alan H.

PY - 2008

Y1 - 2008

N2 - Hexanic, methanolic, and hydroalcoholic extracts, and 34 isolated compounds from Vitex polygama Cham. (Lamiaceae, formely Verbenaceae) and Siphoneugena densiflora O. Berg (Myrtaceae) were screened for their trypanocidal effects on bloodstream forms of Trypanosoma cruzi and T brucei, as well as for their enzymatic inhibitory activities on glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) and trypanothione reductase (TR) enzymes from T cruzi and adeninephosphoribosyl transferase (APRT) enzyme from Leishmania tarentolae. In general, polar extracts displayed strong effects and some of the tested compounds have shown good results in comparison to positive controls of the bioassays.

AB - Hexanic, methanolic, and hydroalcoholic extracts, and 34 isolated compounds from Vitex polygama Cham. (Lamiaceae, formely Verbenaceae) and Siphoneugena densiflora O. Berg (Myrtaceae) were screened for their trypanocidal effects on bloodstream forms of Trypanosoma cruzi and T brucei, as well as for their enzymatic inhibitory activities on glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) and trypanothione reductase (TR) enzymes from T cruzi and adeninephosphoribosyl transferase (APRT) enzyme from Leishmania tarentolae. In general, polar extracts displayed strong effects and some of the tested compounds have shown good results in comparison to positive controls of the bioassays.

KW - myrtaceae

KW - Trypanosoma

KW - Leishmania

KW - PLANT-EXTRACTS

KW - CONSTITUENTS

KW - IDENTIFICATION

KW - METABOLISM

KW - MYRTACEAE

KW - TRYPANOTHIONE

KW - TRYPANOSOMES

KW - FLAVONOIDS

KW - FEATURES

M3 - Article

SN - 0939-5075

VL - 63

SP - 371

EP - 382

JO - Zeitschrift für Naturforschung C: a Journal of Biosciences

JF - Zeitschrift für Naturforschung C: a Journal of Biosciences

IS - 5-6

ER -

Enzymatic inhibitory activity and trypanocidal effects of extracts and compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham.

Abstract

Keywords

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