Enzymatic inhibitory activity and trypanocidal effects of extracts and compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham.

Margareth B. C. Gallo, Anna Sylvia F. Marques, Paulo C. Vieira, Maria Fatima das G. F. da Silva, Joao B. Fernandes, Marcio Silva, Rafael V. Guido, Glaucius Oliva, Otavio H. Thiemann, Sergio Albuquerque, Alan H. Fairlamb

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    12 Citations (Scopus)

    Abstract

    Hexanic, methanolic, and hydroalcoholic extracts, and 34 isolated compounds from Vitex polygama Cham. (Lamiaceae, formely Verbenaceae) and Siphoneugena densiflora O. Berg (Myrtaceae) were screened for their trypanocidal effects on bloodstream forms of Trypanosoma cruzi and T brucei, as well as for their enzymatic inhibitory activities on glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) and trypanothione reductase (TR) enzymes from T cruzi and adeninephosphoribosyl transferase (APRT) enzyme from Leishmania tarentolae. In general, polar extracts displayed strong effects and some of the tested compounds have shown good results in comparison to positive controls of the bioassays.

    Original languageEnglish
    Pages (from-to)371-382
    Number of pages12
    JournalZeitschrift für Naturforschung C: a Journal of Biosciences
    Volume63
    Issue number5-6
    Publication statusPublished - 2008

    Keywords

    • myrtaceae
    • Trypanosoma
    • Leishmania
    • PLANT-EXTRACTS
    • CONSTITUENTS
    • IDENTIFICATION
    • METABOLISM
    • MYRTACEAE
    • TRYPANOTHIONE
    • TRYPANOSOMES
    • FLAVONOIDS
    • FEATURES

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