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Methods: 145 participants (mean age 63.9 ± 8.1 years; 61% male) were evaluated. All patients underwent cardiovascular magnetic resonance (CMR) examination and PWV. EAT measurements from CMR were performed on the 4-chamber view. Blood samples were taken and a range of CV biomarkers was evaluated.
Results: EAT measurements were significantly higher in the groups with CVD, with or without T2DM compared to patients without CVD or T2DM (group 1 EAT 15.9 ± 5.5 cm² vs. group 4 EAT 11.8 ± 4.1 cm2, p=0.001; group 3 EAT 15.1 ± 4.3cm² vs. group 4 EAT 11.8 ± 4.1 cm2, p=0.024). EAT was independently associated with IL-6 (beta 0.2, p=0.019). When added to clinical variables, both EAT (beta 0.16, p=0.035) and IL-6 (beta 0.26, p=0.003) were independently associated with PWV. EAT was significantly associated with LVMI in a univariable analysis but not when added to significant clinical variables.
Conclusions: In patients with cardio-metabolic disease, EAT was independently associated with PWV. EAT may be associated with CVD risk due to an increase in systemic vascular inflammation. Whether targeting EAT may reduce inflammation and/or cardiovascular risk should be evaluated in prospective studies.
- Epicardial adipose tissue
- pulse wave velocity
- artifical stiffness
- cardiovascular magnetic resonance
- left ventricular mass
- Type 2 diabetes mellitus
- Arterial stiffness
- Cardiovascular magnetic resonance
- Pulse wave velocity
- Left ventricular mass
- Pulse Wave Analysis
- Middle Aged
- Adipose Tissue/diagnostic imaging
- Diabetes Mellitus, Type 2/diagnosis
- Case-Control Studies
- Vascular Stiffness
- Cardiovascular Diseases/diagnosis
- Risk Factors
- Magnetic Resonance Imaging, Cine