Epidemiology and Microbiology of Bacterial Bloodstream Infection in a Tertiary Hospital in Nigeria

Garba Iliyasu; Farouq Muhammad Dayyab; Aliyu Aminu; Sadiq Halilu; Salisu Abubakar; Salisu Inuwa; Abdulrazaq Garba Habib

doi:10.1097/IPC.0000000000000783

Epidemiology and Microbiology of Bacterial Bloodstream Infection in a Tertiary Hospital in Nigeria

Garba Iliyasu, Farouq Muhammad Dayyab, Aliyu Aminu, Sadiq Halilu, Salisu Abubakar, Salisu Inuwa, Abdulrazaq Garba Habib

Research output: Contribution to journal › Article › peer-review

Abstract

Background
Bacterial bloodstream infections (BSIs) are a significant cause of morbidity and mortality among hospitalized patients, and data in resource-limited countries are sparse.

Methods
A hospital-wide retrospective analysis of microbiologically proven bacteremia was conducted. Sociodemographic data, comorbidities, bacterial isolates, and their antimicrobial susceptibility pattern were recorded.

Results
Of the 276 episodes of bacteremia studied, 130 (47.1%) occurred in females. The overall mean age was 15.29 ± 23.22 years. Community-acquired BSI was seen in 179 (65.0%) of the patients, whereas 97 (35%) was hospital-acquired BSI. Gram-negative bacteria 158 (57.2%) were the leading cause of BSI. More than 60% of the isolates were resistant to commonly prescribed antibiotics, especially trimethoprim-sulfamethoxazole, ampicillin, and amoxicillin–clavulanic acid.

Conclusions
Gram-negative bacteria are the leading cause of bacteremia with resistance to commonly prescribed antibiotics.

Original language	English
Pages (from-to)	16-21
Number of pages	6
Journal	Infectious Diseases in Clinical Practice
Volume	28
Issue number	1
DOIs	https://doi.org/10.1097/IPC.0000000000000783
Publication status	Published - Jan 2020

Keywords

antimicrobial resistance
bloodstream infections
community-acquired bloodstream infections
hospital-acquired bloodstream infections
multidrug resistance

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@article{2d3b99eef1384f3bb5e65ac494f0f96c,

title = "Epidemiology and Microbiology of Bacterial Bloodstream Infection in a Tertiary Hospital in Nigeria",

abstract = "Background Bacterial bloodstream infections (BSIs) are a significant cause of morbidity and mortality among hospitalized patients, and data in resource-limited countries are sparse.Methods A hospital-wide retrospective analysis of microbiologically proven bacteremia was conducted. Sociodemographic data, comorbidities, bacterial isolates, and their antimicrobial susceptibility pattern were recorded.Results Of the 276 episodes of bacteremia studied, 130 (47.1%) occurred in females. The overall mean age was 15.29 ± 23.22 years. Community-acquired BSI was seen in 179 (65.0%) of the patients, whereas 97 (35%) was hospital-acquired BSI. Gram-negative bacteria 158 (57.2%) were the leading cause of BSI. More than 60% of the isolates were resistant to commonly prescribed antibiotics, especially trimethoprim-sulfamethoxazole, ampicillin, and amoxicillin–clavulanic acid.Conclusions Gram-negative bacteria are the leading cause of bacteremia with resistance to commonly prescribed antibiotics.",

keywords = "antimicrobial resistance, bloodstream infections, community-acquired bloodstream infections, hospital-acquired bloodstream infections, multidrug resistance",

author = "Garba Iliyasu and Dayyab, {Farouq Muhammad} and Aliyu Aminu and Sadiq Halilu and Salisu Abubakar and Salisu Inuwa and Habib, {Abdulrazaq Garba}",

year = "2020",

month = jan,

doi = "10.1097/IPC.0000000000000783",

language = "English",

volume = "28",

pages = "16--21",

journal = "Infectious Diseases in Clinical Practice",

issn = "1056-9103",

publisher = "Lippincott, Williams & Wilkins",

number = "1",

}

Epidemiology and Microbiology of Bacterial Bloodstream Infection in a Tertiary Hospital in Nigeria. / Iliyasu, Garba; Dayyab, Farouq Muhammad; Aminu, Aliyu; Halilu, Sadiq; Abubakar, Salisu; Inuwa, Salisu; Habib, Abdulrazaq Garba.

In: Infectious Diseases in Clinical Practice, Vol. 28, No. 1, 01.2020, p. 16-21.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Epidemiology and Microbiology of Bacterial Bloodstream Infection in a Tertiary Hospital in Nigeria

AU - Iliyasu, Garba

AU - Dayyab, Farouq Muhammad

AU - Aminu, Aliyu

AU - Halilu, Sadiq

AU - Abubakar, Salisu

AU - Inuwa, Salisu

AU - Habib, Abdulrazaq Garba

PY - 2020/1

Y1 - 2020/1

N2 - Background Bacterial bloodstream infections (BSIs) are a significant cause of morbidity and mortality among hospitalized patients, and data in resource-limited countries are sparse.Methods A hospital-wide retrospective analysis of microbiologically proven bacteremia was conducted. Sociodemographic data, comorbidities, bacterial isolates, and their antimicrobial susceptibility pattern were recorded.Results Of the 276 episodes of bacteremia studied, 130 (47.1%) occurred in females. The overall mean age was 15.29 ± 23.22 years. Community-acquired BSI was seen in 179 (65.0%) of the patients, whereas 97 (35%) was hospital-acquired BSI. Gram-negative bacteria 158 (57.2%) were the leading cause of BSI. More than 60% of the isolates were resistant to commonly prescribed antibiotics, especially trimethoprim-sulfamethoxazole, ampicillin, and amoxicillin–clavulanic acid.Conclusions Gram-negative bacteria are the leading cause of bacteremia with resistance to commonly prescribed antibiotics.

AB - Background Bacterial bloodstream infections (BSIs) are a significant cause of morbidity and mortality among hospitalized patients, and data in resource-limited countries are sparse.Methods A hospital-wide retrospective analysis of microbiologically proven bacteremia was conducted. Sociodemographic data, comorbidities, bacterial isolates, and their antimicrobial susceptibility pattern were recorded.Results Of the 276 episodes of bacteremia studied, 130 (47.1%) occurred in females. The overall mean age was 15.29 ± 23.22 years. Community-acquired BSI was seen in 179 (65.0%) of the patients, whereas 97 (35%) was hospital-acquired BSI. Gram-negative bacteria 158 (57.2%) were the leading cause of BSI. More than 60% of the isolates were resistant to commonly prescribed antibiotics, especially trimethoprim-sulfamethoxazole, ampicillin, and amoxicillin–clavulanic acid.Conclusions Gram-negative bacteria are the leading cause of bacteremia with resistance to commonly prescribed antibiotics.

KW - antimicrobial resistance

KW - bloodstream infections

KW - community-acquired bloodstream infections

KW - hospital-acquired bloodstream infections

KW - multidrug resistance

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