Epidemiology and Microbiology of Bacterial Bloodstream Infection in a Tertiary Hospital in Nigeria

TY - JOUR

T1 - Epidemiology and Microbiology of Bacterial Bloodstream Infection in a Tertiary Hospital in Nigeria

AU - Iliyasu, Garba

AU - Dayyab, Farouq Muhammad

AU - Aminu, Aliyu

AU - Halilu, Sadiq

AU - Abubakar, Salisu

AU - Inuwa, Salisu

AU - Habib, Abdulrazaq Garba

N1 - Copyright: © 2019 Wolters Kluwer Health, Inc. All rights reserved.

PY - 2020/1

Y1 - 2020/1

N2 - Background: Bacterial bloodstream infections (BSIs) are a significant cause of morbidity and mortality among hospitalized patients, and data in resource-limited countries are sparse. Methods: A hospital-wide retrospective analysis of microbiologically proven bacteremia was conducted. Sociodemographic data, comorbidities, bacterial isolates, and their antimicrobial susceptibility pattern were recorded. Results: Of the 276 episodes of bacteremia studied, 130 (47.1%) occurred in females. The overall mean age was 15.29 ± 23.22 years. Community-acquired BSI was seen in 179 (65.0%) of the patients, whereas 97 (35%) was hospital-acquired BSI. Gram-negative bacteria 158 (57.2%) were the leading cause of BSI. More than 60% of the isolates were resistant to commonly prescribed antibiotics, especially trimethoprim-sulfamethoxazole, ampicillin, and amoxicillin–clavulanic acid. Conclusions: Gram-negative bacteria are the leading cause of bacteremia with resistance to commonly prescribed antibiotics.

AB - Background: Bacterial bloodstream infections (BSIs) are a significant cause of morbidity and mortality among hospitalized patients, and data in resource-limited countries are sparse. Methods: A hospital-wide retrospective analysis of microbiologically proven bacteremia was conducted. Sociodemographic data, comorbidities, bacterial isolates, and their antimicrobial susceptibility pattern were recorded. Results: Of the 276 episodes of bacteremia studied, 130 (47.1%) occurred in females. The overall mean age was 15.29 ± 23.22 years. Community-acquired BSI was seen in 179 (65.0%) of the patients, whereas 97 (35%) was hospital-acquired BSI. Gram-negative bacteria 158 (57.2%) were the leading cause of BSI. More than 60% of the isolates were resistant to commonly prescribed antibiotics, especially trimethoprim-sulfamethoxazole, ampicillin, and amoxicillin–clavulanic acid. Conclusions: Gram-negative bacteria are the leading cause of bacteremia with resistance to commonly prescribed antibiotics.

KW - antimicrobial resistance

KW - bloodstream infections

KW - community-acquired bloodstream infections

KW - hospital-acquired bloodstream infections

KW - multidrug resistance

UR - https://www.scopus.com/pages/publications/85077876108

U2 - 10.1097/IPC.0000000000000783

DO - 10.1097/IPC.0000000000000783

M3 - Article

AN - SCOPUS:85077876108

SN - 1056-9103

VL - 28

SP - 16

EP - 21

JO - Infectious Diseases in Clinical Practice

JF - Infectious Diseases in Clinical Practice

IS - 1

ER -