Epidermal growth factor receptor expression in Barrett's esophagus

D. N. Poller, R. J. C. Steele, K. Morrell

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)

    Abstract

    Six cases of known Barrett's esophagus were examined immunohistochemically for the presence of epidermal growth factor receptor. All cases showed expression of epidermal growth factor receptor in intestinal metaplastic Barrett's epithelium, the most common form of Barrett's change. Expression of epidermal growth factor receptor may be important in neoplastic transformation in Barrett's esophagus, possibly by an autocrine mechanism. Alternatively, epidermal growth factor receptor expression in intestinal metaplastic Barrett's epithelium may represent a nonneoplastic regenerative phenomenon as seen at other sites within the gastrointestinal tract. Further larger studies are required to assess the clinical significance of these findings.
    Original languageEnglish
    Pages (from-to)1226-1227
    Number of pages2
    JournalArchives of Pathology and Laboratory Medicine
    Volume116
    Issue number11
    Publication statusPublished - 1992

    Keywords

    • Barrett Esophagus
    • Epithelium
    • Esophagus
    • Gastric Mucosa
    • Humans
    • Immunohistochemistry
    • Metaplasia
    • Mucous Membrane
    • Receptor, Epidermal Growth Factor

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