Epidermal growth factor receptor expression in colorectal cancer

R. J. C. Steele, P. Kelly, B. Ellul, O. Eremin

    Research output: Contribution to journalArticle

    77 Citations (Scopus)

    Abstract

    Epidermal growth factor (EGF) receptor expression was estimated in 50 invasive human colorectal cancers using immunohistochemistry and the degree of expression was quantified from integrated optical density measurements on the stained sections. All tumours stained positively, but Dukes' C tumours exhibited significantly higher levels of receptor than either Dukes' A or B tumours. In addition, histologically high grade cancers expressed receptors more strongly than those of low grade. It is concluded that a high EGF receptor concentration is associated with poor prognostic factors in colorectal malignancy.
    Original languageEnglish
    Pages (from-to)1352-1354
    Number of pages3
    JournalBritish Journal of Surgery
    Volume77
    Issue number12
    DOIs
    Publication statusPublished - 1990

    Keywords

    • Aged
    • Aged, 80 and over
    • Colorectal Neoplasms
    • Female
    • Humans
    • Immunohistochemistry
    • Male
    • Middle Aged
    • Prognosis
    • Receptor, Epidermal Growth Factor

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