Projects per year
In this issue of Molecular Cell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a surprising mechanism: ARF physically interacts with and antagonizes activation by acetylation of the master redox regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.
|Number of pages||3|
|Publication status||Published - 5 Oct 2017|
FingerprintDive into the research topics of 'Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions'. Together they form a unique fingerprint.
- 2 Finished
Contribution by NRF2 Upregulation to Lung Carcinogenesis and the Possible Therapeutic Value of NRF2 Inhibition by GSK-3 (Joint with Universities of St Andrews, Edinburgh and Pennsylvania)
Dinkova-Kostova, A., Hayes, J., Henderson, C., Keyse, S., Lamond, A. & Sutherland, C.
1/05/16 → 31/10/19