Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions

John D. Hayes (Lead / Corresponding author), Albena T. Dinkova-Kostova

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    3 Citations (Scopus)
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    Abstract

    In this issue of Molecular Cell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a surprising mechanism: ARF physically interacts with and antagonizes activation by acetylation of the master redox regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.

    Original languageEnglish
    Pages (from-to)5-7
    Number of pages3
    JournalMolecular Cell
    Volume68
    Issue number1
    DOIs
    Publication statusPublished - 5 Oct 2017

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    Epigenomics
    Antioxidants
    Tumor Suppressor Proteins
    Acetylation
    Oxidation-Reduction
    Neoplasms

    Cite this

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    title = "Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions",
    abstract = "In this issue of Molecular Cell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a surprising mechanism: ARF physically interacts with and antagonizes activation by acetylation of the master redox regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.",
    author = "Hayes, {John D.} and Dinkova-Kostova, {Albena T.}",
    note = "The authors are supported by grant MR/N009851/1 from the Medical Research Council of the UK and grant C20953/A18644 from Cancer Research UK.",
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    AU - Dinkova-Kostova, Albena T.

    N1 - The authors are supported by grant MR/N009851/1 from the Medical Research Council of the UK and grant C20953/A18644 from Cancer Research UK.

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    N2 - In this issue of Molecular Cell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a surprising mechanism: ARF physically interacts with and antagonizes activation by acetylation of the master redox regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.

    AB - In this issue of Molecular Cell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a surprising mechanism: ARF physically interacts with and antagonizes activation by acetylation of the master redox regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.

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