Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions

John D. Hayes (Lead / Corresponding author), Albena T. Dinkova-Kostova

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    In this issue of Molecular Cell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a surprising mechanism: ARF physically interacts with and antagonizes activation by acetylation of the master redox regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.

    Original languageEnglish
    Pages (from-to)5-7
    Number of pages3
    JournalMolecular Cell
    Issue number1
    Publication statusPublished - 5 Oct 2017


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