Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions

John D. Hayes (Lead / Corresponding author), Albena T. Dinkova-Kostova

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)
    276 Downloads (Pure)

    Abstract

    In this issue of Molecular Cell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a surprising mechanism: ARF physically interacts with and antagonizes activation by acetylation of the master redox regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.

    Original languageEnglish
    Pages (from-to)5-7
    Number of pages3
    JournalMolecular Cell
    Volume68
    Issue number1
    DOIs
    Publication statusPublished - 5 Oct 2017

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