Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions

John D. Hayes; Albena T. Dinkova-Kostova

doi:10.1016/j.molcel.2017.09.023

Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions

John D. Hayes (Lead / Corresponding author), Albena T. Dinkova-Kostova

Research output: Contribution to journal › Article › peer-review

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Abstract

In this issue of Molecular Cell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a surprising mechanism: ARF physically interacts with and antagonizes activation by acetylation of the master redox regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.

Original language	English
Pages (from-to)	5-7
Number of pages	3
Journal	Molecular Cell
Volume	68
Issue number	1
DOIs	https://doi.org/10.1016/j.molcel.2017.09.023
Publication status	Published - 5 Oct 2017

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10.1016/j.molcel.2017.09.023

Author Accepted Manuscript
© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 197 KBLicence: CC BY-NC-ND
Author Accepted Manuscript - Figures
© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 193 KBLicence: CC BY-NC-ND

Contribution by NRF2 Upregulation to Lung Carcinogenesis and the Possible Therapeutic Value of NRF2 Inhibition by GSK-3 (Joint with Universities of St Andrews, Edinburgh and Pennsylvania)
Dinkova-Kostova, A. (Investigator), Hayes, J. (Investigator), Henderson, C. (Investigator), Keyse, S. (Investigator), Lamond, A. (Investigator) & Sutherland, C. (Investigator)
Medical Research Council
1/05/16 → 31/10/19
Project: Research
The Spatiotemporal Regulation of the Keap1/Nrf2 Pathway (Joint with University College London)
Dinkova-Kostova, A. (Investigator)
Biotechnology and Biological Sciences Research Council
30/09/14 → 27/02/18
Project: Research

Cite this

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title = "Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions",

abstract = "In this issue of Molecular Cell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a surprising mechanism: ARF physically interacts with and antagonizes activation by acetylation of the master redox regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.",

author = "Hayes, {John D.} and Dinkova-Kostova, {Albena T.}",

note = "The authors are supported by grant MR/N009851/1 from the Medical Research Council of the UK and grant C20953/A18644 from Cancer Research UK.",

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doi = "10.1016/j.molcel.2017.09.023",

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AU - Hayes, John D.

AU - Dinkova-Kostova, Albena T.

N1 - The authors are supported by grant MR/N009851/1 from the Medical Research Council of the UK and grant C20953/A18644 from Cancer Research UK.

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Y1 - 2017/10/5

N2 - In this issue of Molecular Cell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a surprising mechanism: ARF physically interacts with and antagonizes activation by acetylation of the master redox regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.

AB - In this issue of Molecular Cell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a surprising mechanism: ARF physically interacts with and antagonizes activation by acetylation of the master redox regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.

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DO - 10.1016/j.molcel.2017.09.023

M3 - Article

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EP - 7

JO - Molecular Cell

JF - Molecular Cell

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ER -

Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions

Abstract

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Projects

Contribution by NRF2 Upregulation to Lung Carcinogenesis and the Possible Therapeutic Value of NRF2 Inhibition by GSK-3 (Joint with Universities of St Andrews, Edinburgh and Pennsylvania)

The Spatiotemporal Regulation of the Keap1/Nrf2 Pathway (Joint with University College London)

Cite this