Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions

John D. Hayes; Albena T. Dinkova-Kostova

doi:10.1016/j.molcel.2017.09.023

Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions

John D. Hayes (Lead / Corresponding author)
, Albena T. Dinkova-Kostova

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

453 Downloads (Pure)

Abstract

In this issue of Molecular Cell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a surprising mechanism: ARF physically interacts with and antagonizes activation by acetylation of the master redox regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.

Original language	English
Pages (from-to)	5-7
Number of pages	3
Journal	Molecular Cell
Volume	68
Issue number	1
DOIs	https://doi.org/10.1016/j.molcel.2017.09.023
Publication status	Published - 5 Oct 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.molcel.2017.09.023

Author Accepted Manuscript
© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 197 KBLicence: CC BY-NC-ND
Author Accepted Manuscript - Figures
© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 193 KBLicence: CC BY-NC-ND

Contribution by NRF2 Upregulation to Lung Carcinogenesis and the Possible Therapeutic Value of NRF2 Inhibition by GSK-3 (Joint with Universities of St Andrews, Edinburgh and Pennsylvania)
Dinkova-Kostova, A. (Investigator), Hayes, J. (Investigator), Henderson, C. (Investigator), Keyse, S. (Investigator), Lamond, A. (Investigator) & Sutherland, C. (Investigator)
1/05/16 → 31/10/19
Project: Research
The Spatiotemporal Regulation of the Keap1/Nrf2 Pathway (Joint with University College London)
Dinkova-Kostova, A. (Investigator)
Biotechnology and Biological Sciences Research Council
30/09/14 → 27/02/18
Project: Research

Cite this

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title = "Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions",

abstract = "In this issue of Molecular Cell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a surprising mechanism: ARF physically interacts with and antagonizes activation by acetylation of the master redox regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.",

author = "Hayes, \{John D.\} and Dinkova-Kostova, \{Albena T.\}",

note = "The authors are supported by grant MR/N009851/1 from the Medical Research Council of the UK and grant C20953/A18644 from Cancer Research UK.",

year = "2017",

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doi = "10.1016/j.molcel.2017.09.023",

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T1 - Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions

AU - Hayes, John D.

AU - Dinkova-Kostova, Albena T.

N1 - The authors are supported by grant MR/N009851/1 from the Medical Research Council of the UK and grant C20953/A18644 from Cancer Research UK.

PY - 2017/10/5

Y1 - 2017/10/5

N2 - In this issue of Molecular Cell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a surprising mechanism: ARF physically interacts with and antagonizes activation by acetylation of the master redox regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.

AB - In this issue of Molecular Cell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a surprising mechanism: ARF physically interacts with and antagonizes activation by acetylation of the master redox regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.

U2 - 10.1016/j.molcel.2017.09.023

DO - 10.1016/j.molcel.2017.09.023

M3 - Article

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SP - 5

EP - 7

JO - Molecular Cell

JF - Molecular Cell

IS - 1

ER -

Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions

Abstract

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Projects

Contribution by NRF2 Upregulation to Lung Carcinogenesis and the Possible Therapeutic Value of NRF2 Inhibition by GSK-3 (Joint with Universities of St Andrews, Edinburgh and Pennsylvania)

The Spatiotemporal Regulation of the Keap1/Nrf2 Pathway (Joint with University College London)

Cite this