Epigenetic risks related to assisted reproductive technologies: epigenetics, imprinting, ART and icebergs?

Eamonn R. Maher, Masoud Afnan, Christopher L Barratt

Research output: Contribution to journalArticle

200 Citations (Scopus)

Abstract

Recently, a series of case reports and small studies has suggested that births involving assisted reproductive technology (ART) may have an increased risk of imprinting disorders such as Beckwith-Wiedemann syndrome and Angelman syndrome. Herein, the significance and implications of these findings are discussed. It is speculated that, although such imprinting disorders may be shown to be only rare complications of ART, epigenetic errors might account for a much wider spectrum of ART-related complications than is recognized currently. Addressing these questions should be a priority for research on cohorts of ART children.

Original languageEnglish
Pages (from-to)2508-2511
Number of pages4
JournalHuman Reproduction
Volume18
Issue number12
DOIs
Publication statusPublished - Dec 2003

Keywords

  • Angelman Syndrome/epidemiology
  • Beckwith-Wiedemann Syndrome/epidemiology
  • Epigenesis, Genetic
  • Female
  • Genetic Diseases, Inborn/epidemiology
  • Genomic Imprinting
  • Humans
  • Pregnancy
  • Reproductive Techniques, Assisted/adverse effects
  • Risk Factors

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