Erythropoietin significantly, reversibly, and reproducibly increased in-vitro whole-blood spontaneous platelet aggregation in 15 patients on haemodialysis. During erythropoietin treatment, spontaneous platelet aggregation was significantly higher in these subjects than in non-uraemic controls; concomitant treatment with 300 mg aspirin daily reversed platelet hyperaggregability. Erythropoietin may promote thrombosis by an effect on platelet function.
Taylor, J. E., Henderson, I. S., Stewart, W. K., & Belch, J. J. F. (1991). Erythropoietin and spontaneous platelet aggregation in haemodialysis patients. Lancet, 338(8779), 1361-13622. https://doi.org/10.1016/0140-6736(91)92239-X