Erythropoietin and spontaneous platelet aggregation in haemodialysis patients

J.E. Taylor; I.S. Henderson; W.K. Stewart; J.J.F. Belch

doi:10.1016/0140-6736(91)92239-X

Erythropoietin and spontaneous platelet aggregation in haemodialysis patients

J.E. Taylor, I.S. Henderson, W.K. Stewart, J.J.F. Belch

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Abstract

Erythropoietin significantly, reversibly, and reproducibly increased in-vitro whole-blood spontaneous platelet aggregation in 15 patients on haemodialysis. During erythropoietin treatment, spontaneous platelet aggregation was significantly higher in these subjects than in non-uraemic controls; concomitant treatment with 300 mg aspirin daily reversed platelet hyperaggregability. Erythropoietin may promote thrombosis by an effect on platelet function.

Original language	English
Pages (from-to)	1361-13622
Number of pages	2
Journal	Lancet
Volume	338
Issue number	8779
DOIs	https://doi.org/10.1016/0140-6736(91)92239-X
Publication status	Published - 30 Nov 1991

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title = "Erythropoietin and spontaneous platelet aggregation in haemodialysis patients",

abstract = "Erythropoietin significantly, reversibly, and reproducibly increased in-vitro whole-blood spontaneous platelet aggregation in 15 patients on haemodialysis. During erythropoietin treatment, spontaneous platelet aggregation was significantly higher in these subjects than in non-uraemic controls; concomitant treatment with 300 mg aspirin daily reversed platelet hyperaggregability. Erythropoietin may promote thrombosis by an effect on platelet function.",

author = "J.E. Taylor and I.S. Henderson and W.K. Stewart and J.J.F. Belch",

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AU - Taylor, J.E.

AU - Henderson, I.S.

AU - Stewart, W.K.

AU - Belch, J.J.F.

PY - 1991/11/30

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N2 - Erythropoietin significantly, reversibly, and reproducibly increased in-vitro whole-blood spontaneous platelet aggregation in 15 patients on haemodialysis. During erythropoietin treatment, spontaneous platelet aggregation was significantly higher in these subjects than in non-uraemic controls; concomitant treatment with 300 mg aspirin daily reversed platelet hyperaggregability. Erythropoietin may promote thrombosis by an effect on platelet function.

AB - Erythropoietin significantly, reversibly, and reproducibly increased in-vitro whole-blood spontaneous platelet aggregation in 15 patients on haemodialysis. During erythropoietin treatment, spontaneous platelet aggregation was significantly higher in these subjects than in non-uraemic controls; concomitant treatment with 300 mg aspirin daily reversed platelet hyperaggregability. Erythropoietin may promote thrombosis by an effect on platelet function.

U2 - 10.1016/0140-6736(91)92239-X

DO - 10.1016/0140-6736(91)92239-X

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JO - Lancet

JF - Lancet

IS - 8779

ER -

Erythropoietin and spontaneous platelet aggregation in haemodialysis patients

Abstract

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