Erythropoietin and spontaneous platelet aggregation in haemodialysis patients

J.E. Taylor, I.S. Henderson, W.K. Stewart, J.J.F. Belch

    Research output: Contribution to journalArticle

    57 Citations (Scopus)

    Abstract

    Erythropoietin significantly, reversibly, and reproducibly increased in-vitro whole-blood spontaneous platelet aggregation in 15 patients on haemodialysis. During erythropoietin treatment, spontaneous platelet aggregation was significantly higher in these subjects than in non-uraemic controls; concomitant treatment with 300 mg aspirin daily reversed platelet hyperaggregability. Erythropoietin may promote thrombosis by an effect on platelet function.
    Original languageEnglish
    Pages (from-to)1361-13622
    Number of pages2
    JournalLancet
    Volume338
    Issue number8779
    DOIs
    Publication statusPublished - 30 Nov 1991

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