Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate

Amit Grover, Elena Mancini, Susan Moore, Adam J. Mead, Deborah Atkinson, Kasper D. Rasmussen, Donal O'Carroll, Sten Eirik W. Jacobsen, Claus Nerlov (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)
121 Downloads (Pure)

Abstract

The erythroid stress cytokine erythropoietin (Epo) supports the development of committed erythroid progenitors, but its ability to act on upstream, multipotent cells remains to be established. We observe that high systemic levels of Epo reprogram the transcriptomes of multi-and bipotent hematopoietic stem/progenitor cells in vivo. This induces erythroid lineage bias at all lineage bifurcations known to exist between hematopoietic stem cells (HSCs) and committed erythroid progenitors, leading to increased erythroid and decreased myeloid HSC output. Epo, therefore, has a lineage instructive role in vivo, through suppression of non-erythroid fate options, demonstrating the ability of a cytokine to systematically bias successive lineage choices in favor of the generation of a specific cell type.

Original languageEnglish
Pages (from-to)181-188
Number of pages8
JournalJournal of Experimental Medicine
Volume211
Issue number2
Early online date3 Feb 2014
DOIs
Publication statusPublished - 10 Feb 2014

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