Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate

TY - JOUR

T1 - Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate

AU - Grover, Amit

AU - Mancini, Elena

AU - Moore, Susan

AU - Mead, Adam J.

AU - Atkinson, Deborah

AU - Rasmussen, Kasper D.

AU - O'Carroll, Donal

AU - Jacobsen, Sten Eirik W.

AU - Nerlov, Claus

PY - 2014/2/10

Y1 - 2014/2/10

N2 - The erythroid stress cytokine erythropoietin (Epo) supports the development of committed erythroid progenitors, but its ability to act on upstream, multipotent cells remains to be established. We observe that high systemic levels of Epo reprogram the transcriptomes of multi-and bipotent hematopoietic stem/progenitor cells in vivo. This induces erythroid lineage bias at all lineage bifurcations known to exist between hematopoietic stem cells (HSCs) and committed erythroid progenitors, leading to increased erythroid and decreased myeloid HSC output. Epo, therefore, has a lineage instructive role in vivo, through suppression of non-erythroid fate options, demonstrating the ability of a cytokine to systematically bias successive lineage choices in favor of the generation of a specific cell type.

AB - The erythroid stress cytokine erythropoietin (Epo) supports the development of committed erythroid progenitors, but its ability to act on upstream, multipotent cells remains to be established. We observe that high systemic levels of Epo reprogram the transcriptomes of multi-and bipotent hematopoietic stem/progenitor cells in vivo. This induces erythroid lineage bias at all lineage bifurcations known to exist between hematopoietic stem cells (HSCs) and committed erythroid progenitors, leading to increased erythroid and decreased myeloid HSC output. Epo, therefore, has a lineage instructive role in vivo, through suppression of non-erythroid fate options, demonstrating the ability of a cytokine to systematically bias successive lineage choices in favor of the generation of a specific cell type.

UR - https://www.scopus.com/pages/publications/84893804457

U2 - 10.1084/jem.20131189

DO - 10.1084/jem.20131189

M3 - Article

C2 - 24493804

AN - SCOPUS:84893804457

SN - 0022-1007

VL - 211

SP - 181

EP - 188

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

IS - 2

ER -