TY - JOUR
T1 - Escape from senescence
T2 - molecular basis and therapeutic ramifications
AU - Evangelou, Konstantinos
AU - Belogiannis, Konstantinos
AU - Papaspyropoulos, Angelos
AU - Petty, Russell
AU - Gorgoulis, Vassilis G.
N1 - Funding Information:
Ministry of Development and Investment/General Secretariat for Research and Innovation-Flagship Initiative to address SARS-CoV-2. Grant Number: 2020ΣΕ01300001; Flagship Initiative to address SARS-CoV-2. Grant Number: 2020ΣΕ01300001; European Regional Development Fund
European Union and Greek National Funds; RESEARCH-CREATE-INNOVATE. Grant Numbers: T2EDK-03266, T2EDK-02939; Sonia Kotopoulos
Hellenic Foundation for Research and Innovation. Grant Number: 3782; National and Kapodistrian University of Athens-Special Account for Research Grants (SARG). Grant Number: 70/3/8916; Foundation for Education and European Culture (IPEP).
Copyright:
© 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
PY - 2023/8
Y1 - 2023/8
N2 - Cellular senescence constitutes a stress response mechanism in reaction to a plethora of stimuli. Senescent cells exhibit cell-cycle arrest and altered function. While cell-cycle withdrawal has been perceived as permanent, recent evidence in cancer research introduced the so-called escape-from-senescence concept. In particular, under certain conditions, senescent cells may resume proliferation, acquiring highly aggressive features. As such, they have been associated with tumour relapse, rendering senescence less effective in inhibiting cancer progression. Thus, conventional cancer treatments, incapable of eliminating senescence, may benefit if revisited to include senolytic agents. To this end, it is anticipated that the assessment of the senescence burden in everyday clinical material by pathologists will play a crucial role in the near future, laying the foundation for more personalised approaches. Here, we provide an overview of the investigations that introduced the escape-from-senescence phenomenon, the identified mechanisms, as well as the major implications for pathology and therapy.
AB - Cellular senescence constitutes a stress response mechanism in reaction to a plethora of stimuli. Senescent cells exhibit cell-cycle arrest and altered function. While cell-cycle withdrawal has been perceived as permanent, recent evidence in cancer research introduced the so-called escape-from-senescence concept. In particular, under certain conditions, senescent cells may resume proliferation, acquiring highly aggressive features. As such, they have been associated with tumour relapse, rendering senescence less effective in inhibiting cancer progression. Thus, conventional cancer treatments, incapable of eliminating senescence, may benefit if revisited to include senolytic agents. To this end, it is anticipated that the assessment of the senescence burden in everyday clinical material by pathologists will play a crucial role in the near future, laying the foundation for more personalised approaches. Here, we provide an overview of the investigations that introduced the escape-from-senescence phenomenon, the identified mechanisms, as well as the major implications for pathology and therapy.
KW - cellular senescence
KW - senescence escape
KW - cancer
KW - pathology
KW - senolytics
KW - therapy
UR - http://www.scopus.com/inward/record.url?scp=85166947516&partnerID=8YFLogxK
U2 - 10.1002/path.6164
DO - 10.1002/path.6164
M3 - Review article
C2 - 37550877
SN - 0022-3417
VL - 260
SP - 649
EP - 665
JO - The Journal of Pathology
JF - The Journal of Pathology
IS - 5
ER -