Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

W.C. Earnshaw, R.C. Allshire, B.E. Black, K. Bloom, E.D. Salmon, B.R. Brinkley, W. Brown, I.M. Cheeseman, K.H.A. Choo, G.P. Copenhaver, J.G. DeLuca, K. Luger, A. Desai, K. Oegema, D.W. Cleveland, S. Diekmann, S. Erhardt, M. Fitzgerald-Hayes, D. Foltz, T. FukagawaR. Gassmann, H. Maiato, D.W. Gerlich, D.M. Glover, G.J. Gorbsky, S.C. Harrison, P. Heun, T. Hirota, L.E.T. Jansen, G. Karpen, G.J.P.L. Kops, M.A. Lampson, S.M. Lens, A. Losada, P.S. Maddox, R.L. Margolis, H. Masumoto, A.D. McAinsh, B.G. Mellone, R.J. O'Neill, P. Meraldi, A. Musacchio, K.C. Scott, B.A. Sullivan, A.F. Straight, P.T. Stukenberg, K.F. Sullivan, C.E. Sunkel, J.R. Swedlow, C.E. Walczak, P.E. Warburton, S. Westermann, H.F. Willard, L. Wordeman, M. Yanagida, T.J. Yen, K. Yoda

    Research output: Contribution to journalArticlepeer-review

    29 Citations (Scopus)


    The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.
    Original languageEnglish
    Pages (from-to)101-106
    Number of pages6
    JournalChromosome Research
    Issue number2
    Publication statusPublished - 2013


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