Estimating the causal tissues for complex traits and diseases

GTEx Consortium, Halit Ongen (Lead / Corresponding author), Andrew A Brown, Olivier Delaneau, Nikolaos I Panousis, Alexandra C Nica, Emmanouil T Dermitzakis (Lead / Corresponding author)

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

How to interpret the biological causes underlying the predisposing markers identified through genome-wide association studies (GWAS) remains an open question. One direct and powerful way to assess the genetic causality behind GWAS is through analysis of expression quantitative trait loci (eQTLs). Here we describe a new approach to estimate the tissues behind the genetic causality of a variety of GWAS traits, using the cis-eQTLs in 44 tissues from the Genotype-Tissue Expression (GTEx) Consortium. We have adapted the regulatory trait concordance (RTC) score to measure the probability of eQTLs being active in multiple tissues and to calculate the probability that a GWAS-associated variant and an eQTL tag the same functional effect. By normalizing the GWAS-eQTL probabilities by the tissue-sharing estimates for eQTLs, we generate relative tissue-causality profiles for GWAS traits. Our approach not only implicates the gene likely mediating individual GWAS signals, but also highlights tissues where the genetic causality for an individual trait is likely manifested.

Original languageEnglish
Pages (from-to)1676-1683
Number of pages8
JournalNature Genetics
Volume49
Issue number12
DOIs
Publication statusPublished - 23 Oct 2017

Fingerprint

Genome-Wide Association Study
Quantitative Trait Loci
Causality
Genotype
Genes

Keywords

  • Gene Expression Profiling
  • Genetic Association Studies
  • Genetic Predisposition to Disease/genetics
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Organ Specificity/genetics
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci/genetics

Cite this

GTEx Consortium, Ongen, H., Brown, A. A., Delaneau, O., Panousis, N. I., Nica, A. C., & Dermitzakis, E. T. (2017). Estimating the causal tissues for complex traits and diseases. Nature Genetics, 49(12), 1676-1683. https://doi.org/10.1038/ng.3981
GTEx Consortium ; Ongen, Halit ; Brown, Andrew A ; Delaneau, Olivier ; Panousis, Nikolaos I ; Nica, Alexandra C ; Dermitzakis, Emmanouil T. / Estimating the causal tissues for complex traits and diseases. In: Nature Genetics. 2017 ; Vol. 49, No. 12. pp. 1676-1683.
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GTEx Consortium, Ongen, H, Brown, AA, Delaneau, O, Panousis, NI, Nica, AC & Dermitzakis, ET 2017, 'Estimating the causal tissues for complex traits and diseases', Nature Genetics, vol. 49, no. 12, pp. 1676-1683. https://doi.org/10.1038/ng.3981

Estimating the causal tissues for complex traits and diseases. / GTEx Consortium; Ongen, Halit (Lead / Corresponding author); Brown, Andrew A; Delaneau, Olivier; Panousis, Nikolaos I; Nica, Alexandra C; Dermitzakis, Emmanouil T (Lead / Corresponding author).

In: Nature Genetics, Vol. 49, No. 12, 23.10.2017, p. 1676-1683.

Research output: Contribution to journalArticle

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AU - GTEx Consortium

AU - Ongen, Halit

AU - Brown, Andrew A

AU - Delaneau, Olivier

AU - Panousis, Nikolaos I

AU - Nica, Alexandra C

AU - Dermitzakis, Emmanouil T

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KW - Organ Specificity/genetics

KW - Phenotype

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GTEx Consortium, Ongen H, Brown AA, Delaneau O, Panousis NI, Nica AC et al. Estimating the causal tissues for complex traits and diseases. Nature Genetics. 2017 Oct 23;49(12):1676-1683. https://doi.org/10.1038/ng.3981