Projects per year
Cooperativity is an important parameter to understand the ternary complexes formed by protein degraders. We developed fluorine NMR competition binding experiments to determine cooperativity of PROTACs. We show applicability to estimate both positive and negative cooperativity, also with homo-dimerizers, and highlight key features and considerations for optimal assay development.
|Number of pages||6|
|Journal||RSC Medicinal Chemistry|
|Early online date||24 Aug 2021|
|Publication status||Published - Oct 2021|
ASJC Scopus subject areas
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Organic Chemistry
FingerprintDive into the research topics of 'Estimating the cooperativity of PROTAC-induced ternary complexes using 19F NMR displacement assay'. Together they form a unique fingerprint.
- 3 Finished
A Translational Engine for Biomedical Discoveries (Strategic Grant)
1/01/13 → 30/09/15
State-of-the-Art Facilities for Structural Biology at the University of Dundee
Hunter, B., Lilley, D., Owen-Hughes, T., Wyatt, P. & van Aalten, D.
1/03/12 → 28/02/17
- 3 Citations
- 1 Comment/debate
Erratum: Estimating the cooperativity of PROTAC-induced ternary complexes using 19F NMR displacement assay (RSC Med. Chem. (2021) 12 (1765-1770) DOI: 10.1039/D1MD00215E)de Castro, G. V. & Ciulli, A., Jan 2022, In: RSC Medicinal Chemistry. 13, 1, p. 98 1 p.
Research output: Contribution to journal › Comment/debate › peer-reviewOpen AccessFile33 Downloads (Pure)