European Surveillance System on Contact Allergies (ESSCA)

polysensitization, 2009-2014

Daan Dittmar, Wolfgang Uter, Andrea Bauer, Anna B. Fortina, Andreas J. Bircher, Magdalena Czarnecka-Operacz, Aleksandra Dugonik, Peter Elsner, Rosella Gallo, Sharizan A. Ghaffar, Anna Giménez-Arnau, Graham A. Johnston, Beata Kręcisz, Francesca L. Filon, Thomas Rustemeyer, Anna Sadowska-Przytocka, Javier Sánchez-Pérez, Axel Schnuch, Dagmar Simon, Radoslaw Spiewak & 8 others Philipp Spring, Maria T. Corradin, Skaidra Valiukevičienė, Marko Vok, Elke Weisshaar, Mark Wilkinson, Marie L. Schuttelaar, for the ESSCA Network

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    Background: Polysensitization, defined as being allergic to three or more haptens from the European baseline series, is considered to reflect increased susceptibility to developing a contact allergy, and is likely to be associated with an impaired quality of life.

    Objectives: To evaluate the prevalences of polysensitization across Europe and to analyse factors associated with polysensitization.

    Methods: Patch test data collected by the European Surveillance System on Contact Allergies (ESSCA; www.essca-dc.org) in consecutively patch tested patients from January 2009 to December 2014, comprising 11 countries and 57 departments, were retrospectively analysed.

    Results: A total of 86 416 patients were available for analysis, showing a standardized prevalence of polysensitization of 7.02%, ranging from 12.7% (Austria) to 4.6% (Italy). Allergen pairs with the strongest association are reported for the total population, for South Europe, and for North/Central Europe. Overall, polysensitized patients showed a higher percentage of extreme (+++) positive patch test reactions than oligosensitized patients. Female sex, occupational dermatitis and age > 40 years were risk factors for polysensitization.

    Conclusions: The varying prevalences of polysensitization across Europe most likely reflect differences in patient characteristics and referral patterns between departments. Known risk factors for polysensitization are confirmed in a European dermatitis population.

    Original languageEnglish
    Pages (from-to)373-385
    Number of pages13
    JournalContact Dermatitis
    Volume78
    Issue number6
    Early online date22 Feb 2018
    DOIs
    Publication statusPublished - Jun 2018

    Fingerprint

    Hypersensitivity
    Patch Tests
    Occupational Dermatitis
    Haptens
    Austria
    Dermatitis
    Allergens
    Italy
    Population
    Statistical Factor Analysis
    Referral and Consultation
    Quality of Life

    Keywords

    • Journal article
    • Clinical epidemiology
    • Contact allergy
    • Patch test
    • Polysensitization
    • contact allergy
    • clinical epidemiology
    • patch test
    • polysensitization
    • Prevalence
    • Humans
    • Middle Aged
    • Patch Tests/statistics & numerical data
    • Dermatitis, Allergic Contact/epidemiology
    • Young Adult
    • Europe/epidemiology
    • Adult
    • Retrospective Studies
    • Allergens/immunology
    • Dermatitis, Atopic/epidemiology
    • Population Surveillance

    Cite this

    Dittmar, D., Uter, W., Bauer, A., Fortina, A. B., Bircher, A. J., Czarnecka-Operacz, M., ... for the ESSCA Network (2018). European Surveillance System on Contact Allergies (ESSCA): polysensitization, 2009-2014. Contact Dermatitis, 78(6), 373-385. https://doi.org/10.1111/cod.12966
    Dittmar, Daan ; Uter, Wolfgang ; Bauer, Andrea ; Fortina, Anna B. ; Bircher, Andreas J. ; Czarnecka-Operacz, Magdalena ; Dugonik, Aleksandra ; Elsner, Peter ; Gallo, Rosella ; Ghaffar, Sharizan A. ; Giménez-Arnau, Anna ; Johnston, Graham A. ; Kręcisz, Beata ; Filon, Francesca L. ; Rustemeyer, Thomas ; Sadowska-Przytocka, Anna ; Sánchez-Pérez, Javier ; Schnuch, Axel ; Simon, Dagmar ; Spiewak, Radoslaw ; Spring, Philipp ; Corradin, Maria T. ; Valiukevičienė, Skaidra ; Vok, Marko ; Weisshaar, Elke ; Wilkinson, Mark ; Schuttelaar, Marie L. ; for the ESSCA Network. / European Surveillance System on Contact Allergies (ESSCA) : polysensitization, 2009-2014. In: Contact Dermatitis. 2018 ; Vol. 78, No. 6. pp. 373-385.
    @article{f048c4d3d38f4d6f90e93d8976af9f7d,
    title = "European Surveillance System on Contact Allergies (ESSCA): polysensitization, 2009-2014",
    abstract = "Background: Polysensitization, defined as being allergic to three or more haptens from the European baseline series, is considered to reflect increased susceptibility to developing a contact allergy, and is likely to be associated with an impaired quality of life.Objectives: To evaluate the prevalences of polysensitization across Europe and to analyse factors associated with polysensitization.Methods: Patch test data collected by the European Surveillance System on Contact Allergies (ESSCA; www.essca-dc.org) in consecutively patch tested patients from January 2009 to December 2014, comprising 11 countries and 57 departments, were retrospectively analysed.Results: A total of 86 416 patients were available for analysis, showing a standardized prevalence of polysensitization of 7.02{\%}, ranging from 12.7{\%} (Austria) to 4.6{\%} (Italy). Allergen pairs with the strongest association are reported for the total population, for South Europe, and for North/Central Europe. Overall, polysensitized patients showed a higher percentage of extreme (+++) positive patch test reactions than oligosensitized patients. Female sex, occupational dermatitis and age > 40 years were risk factors for polysensitization.Conclusions: The varying prevalences of polysensitization across Europe most likely reflect differences in patient characteristics and referral patterns between departments. Known risk factors for polysensitization are confirmed in a European dermatitis population.",
    keywords = "Journal article, Clinical epidemiology , Contact allergy, Patch test , Polysensitization, contact allergy, clinical epidemiology, patch test, polysensitization, Prevalence, Humans, Middle Aged, Patch Tests/statistics & numerical data, Dermatitis, Allergic Contact/epidemiology, Young Adult, Europe/epidemiology, Adult, Retrospective Studies, Allergens/immunology, Dermatitis, Atopic/epidemiology, Population Surveillance",
    author = "Daan Dittmar and Wolfgang Uter and Andrea Bauer and Fortina, {Anna B.} and Bircher, {Andreas J.} and Magdalena Czarnecka-Operacz and Aleksandra Dugonik and Peter Elsner and Rosella Gallo and Ghaffar, {Sharizan A.} and Anna Gim{\'e}nez-Arnau and Johnston, {Graham A.} and Beata Kręcisz and Filon, {Francesca L.} and Thomas Rustemeyer and Anna Sadowska-Przytocka and Javier S{\'a}nchez-P{\'e}rez and Axel Schnuch and Dagmar Simon and Radoslaw Spiewak and Philipp Spring and Corradin, {Maria T.} and Skaidra Valiukevičienė and Marko Vok and Elke Weisshaar and Mark Wilkinson and Schuttelaar, {Marie L.} and {for the ESSCA Network}",
    note = "The present study was not sponsored; the ESSCAhad received initial start-up funding from the EU(QLK4-CT-2001-00343 and QLK4-CT-2001-2812)in 2002–2004",
    year = "2018",
    month = "6",
    doi = "10.1111/cod.12966",
    language = "English",
    volume = "78",
    pages = "373--385",
    journal = "Contact Dermatitis",
    issn = "0105-1873",
    publisher = "Wiley",
    number = "6",

    }

    Dittmar, D, Uter, W, Bauer, A, Fortina, AB, Bircher, AJ, Czarnecka-Operacz, M, Dugonik, A, Elsner, P, Gallo, R, Ghaffar, SA, Giménez-Arnau, A, Johnston, GA, Kręcisz, B, Filon, FL, Rustemeyer, T, Sadowska-Przytocka, A, Sánchez-Pérez, J, Schnuch, A, Simon, D, Spiewak, R, Spring, P, Corradin, MT, Valiukevičienė, S, Vok, M, Weisshaar, E, Wilkinson, M, Schuttelaar, ML & for the ESSCA Network 2018, 'European Surveillance System on Contact Allergies (ESSCA): polysensitization, 2009-2014', Contact Dermatitis, vol. 78, no. 6, pp. 373-385. https://doi.org/10.1111/cod.12966

    European Surveillance System on Contact Allergies (ESSCA) : polysensitization, 2009-2014. / Dittmar, Daan; Uter, Wolfgang; Bauer, Andrea; Fortina, Anna B.; Bircher, Andreas J.; Czarnecka-Operacz, Magdalena; Dugonik, Aleksandra; Elsner, Peter; Gallo, Rosella; Ghaffar, Sharizan A.; Giménez-Arnau, Anna; Johnston, Graham A.; Kręcisz, Beata; Filon, Francesca L.; Rustemeyer, Thomas; Sadowska-Przytocka, Anna; Sánchez-Pérez, Javier; Schnuch, Axel; Simon, Dagmar; Spiewak, Radoslaw; Spring, Philipp; Corradin, Maria T.; Valiukevičienė, Skaidra; Vok, Marko; Weisshaar, Elke; Wilkinson, Mark; Schuttelaar, Marie L. (Lead / Corresponding author); for the ESSCA Network.

    In: Contact Dermatitis, Vol. 78, No. 6, 06.2018, p. 373-385.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - European Surveillance System on Contact Allergies (ESSCA)

    T2 - polysensitization, 2009-2014

    AU - Dittmar, Daan

    AU - Uter, Wolfgang

    AU - Bauer, Andrea

    AU - Fortina, Anna B.

    AU - Bircher, Andreas J.

    AU - Czarnecka-Operacz, Magdalena

    AU - Dugonik, Aleksandra

    AU - Elsner, Peter

    AU - Gallo, Rosella

    AU - Ghaffar, Sharizan A.

    AU - Giménez-Arnau, Anna

    AU - Johnston, Graham A.

    AU - Kręcisz, Beata

    AU - Filon, Francesca L.

    AU - Rustemeyer, Thomas

    AU - Sadowska-Przytocka, Anna

    AU - Sánchez-Pérez, Javier

    AU - Schnuch, Axel

    AU - Simon, Dagmar

    AU - Spiewak, Radoslaw

    AU - Spring, Philipp

    AU - Corradin, Maria T.

    AU - Valiukevičienė, Skaidra

    AU - Vok, Marko

    AU - Weisshaar, Elke

    AU - Wilkinson, Mark

    AU - Schuttelaar, Marie L.

    AU - for the ESSCA Network

    N1 - The present study was not sponsored; the ESSCAhad received initial start-up funding from the EU(QLK4-CT-2001-00343 and QLK4-CT-2001-2812)in 2002–2004

    PY - 2018/6

    Y1 - 2018/6

    N2 - Background: Polysensitization, defined as being allergic to three or more haptens from the European baseline series, is considered to reflect increased susceptibility to developing a contact allergy, and is likely to be associated with an impaired quality of life.Objectives: To evaluate the prevalences of polysensitization across Europe and to analyse factors associated with polysensitization.Methods: Patch test data collected by the European Surveillance System on Contact Allergies (ESSCA; www.essca-dc.org) in consecutively patch tested patients from January 2009 to December 2014, comprising 11 countries and 57 departments, were retrospectively analysed.Results: A total of 86 416 patients were available for analysis, showing a standardized prevalence of polysensitization of 7.02%, ranging from 12.7% (Austria) to 4.6% (Italy). Allergen pairs with the strongest association are reported for the total population, for South Europe, and for North/Central Europe. Overall, polysensitized patients showed a higher percentage of extreme (+++) positive patch test reactions than oligosensitized patients. Female sex, occupational dermatitis and age > 40 years were risk factors for polysensitization.Conclusions: The varying prevalences of polysensitization across Europe most likely reflect differences in patient characteristics and referral patterns between departments. Known risk factors for polysensitization are confirmed in a European dermatitis population.

    AB - Background: Polysensitization, defined as being allergic to three or more haptens from the European baseline series, is considered to reflect increased susceptibility to developing a contact allergy, and is likely to be associated with an impaired quality of life.Objectives: To evaluate the prevalences of polysensitization across Europe and to analyse factors associated with polysensitization.Methods: Patch test data collected by the European Surveillance System on Contact Allergies (ESSCA; www.essca-dc.org) in consecutively patch tested patients from January 2009 to December 2014, comprising 11 countries and 57 departments, were retrospectively analysed.Results: A total of 86 416 patients were available for analysis, showing a standardized prevalence of polysensitization of 7.02%, ranging from 12.7% (Austria) to 4.6% (Italy). Allergen pairs with the strongest association are reported for the total population, for South Europe, and for North/Central Europe. Overall, polysensitized patients showed a higher percentage of extreme (+++) positive patch test reactions than oligosensitized patients. Female sex, occupational dermatitis and age > 40 years were risk factors for polysensitization.Conclusions: The varying prevalences of polysensitization across Europe most likely reflect differences in patient characteristics and referral patterns between departments. Known risk factors for polysensitization are confirmed in a European dermatitis population.

    KW - Journal article

    KW - Clinical epidemiology

    KW - Contact allergy

    KW - Patch test

    KW - Polysensitization

    KW - contact allergy

    KW - clinical epidemiology

    KW - patch test

    KW - polysensitization

    KW - Prevalence

    KW - Humans

    KW - Middle Aged

    KW - Patch Tests/statistics & numerical data

    KW - Dermatitis, Allergic Contact/epidemiology

    KW - Young Adult

    KW - Europe/epidemiology

    KW - Adult

    KW - Retrospective Studies

    KW - Allergens/immunology

    KW - Dermatitis, Atopic/epidemiology

    KW - Population Surveillance

    UR - http://www.scopus.com/inward/record.url?scp=85046374512&partnerID=8YFLogxK

    U2 - 10.1111/cod.12966

    DO - 10.1111/cod.12966

    M3 - Article

    VL - 78

    SP - 373

    EP - 385

    JO - Contact Dermatitis

    JF - Contact Dermatitis

    SN - 0105-1873

    IS - 6

    ER -

    Dittmar D, Uter W, Bauer A, Fortina AB, Bircher AJ, Czarnecka-Operacz M et al. European Surveillance System on Contact Allergies (ESSCA): polysensitization, 2009-2014. Contact Dermatitis. 2018 Jun;78(6):373-385. https://doi.org/10.1111/cod.12966