Evaluating adaptation options of microcirculatory-tissue systems based on the physiological link of nutritive blood flow and redox ratio

Alexander I. Krupatkin, Victor V. Sidorov, Victor V. Dremin (Lead / Corresponding author), Andrey V. Dunaev, Irina N. Novikova, Simian Zhu, Ghulam Nabi, Karina S. Litvinova, Anastasia P. Baklanova, Ruslan M. Bakshaliev, Sergey A. Ravcheev

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    2 Citations (Scopus)

    Abstract

    Fluorescent spectroscopy (FS) is becoming more widely used in chemistry, biology, in various fields of medical technology and medicine in general. Many purulent wounds, burns and other destructive inflammatory processes are accompanied by changes in the fluorescent activity of the tissues, which occurs due to a misbalance in accumulation of natural fluorophores: FAD, NADH, lipofuscin, porphyrins, structural proteins, etc. The study of redox ratio (RR), characterizing the metabolic processes, is important in the assessment of the metabolic activity ofmicrocirculatory-tissue systems (MTS). However, one of the big problems of the FS method is still the correct interpretation of the data and the development of practical methods for its application in clinical medicine. To solve this problem and create new diagnostic criteria, we propose to evaluate the adaptive capacity of MTS using indicators of links between nutritive blood flow and redox ratio during a physiological rest and functional load (occlusion test). As is known, these parameters (RR and nutritive blood flow) characterize the metabolic activity of tissues.We have performedan experimental study of the relationship between the RR, defined by FS, and nutritive blood flow, defined by the methods of laser Doppler flowmetry. Preliminary results in the study of a complex approach to diagnosis of the state of biological tissue were obtained. A positive relationship between the nutritive blood flow in the microcirculatory channel and RR of skin tissue is observed.The speed of change of metabolism in the phase of occlusion and reperfusion and duration of phase of recovery may be the criteria for adaptive capabilities of MTS, which has practical significance for physiology and medicine.

    Original languageEnglish
    Title of host publicationSaratov Fall Meeting 2014
    Subtitle of host publicationOptical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics
    EditorsElina A. Genina, Vladimir L. Derbov, Kirill V. Larin, Dmitry E. Postnov, Valery V. Tuchin
    Place of PublicationBellingham
    PublisherSPIE-International Society for Optical Engineering
    ISBN (Print)9781628415643
    DOIs
    Publication statusPublished - 2014
    EventSaratov Fall Meeting 2014: Optical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics - Saratov, Russian Federation
    Duration: 23 Sep 201426 Sep 2014
    http://sfm.eventry.org/symposium2014/

    Publication series

    NameProceedings of SPIE
    PublisherSPIE
    Volume9448
    NameProgress in Biomedical Optics and Imaging
    Number53
    Volume16

    Conference

    ConferenceSaratov Fall Meeting 2014: Optical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics
    Abbreviated titleSFM 2014
    CountryRussian Federation
    CitySaratov
    Period23/09/1426/09/14
    Internet address

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    Keywords

    • Fluorescence spectroscopy
    • Laser Doppler flowmetry
    • Metabolism
    • Microcirculatory-tissue system
    • Nutritive blood flow
    • Redox ratio

    Cite this

    Krupatkin, A. I., Sidorov, V. V., Dremin, V. V., Dunaev, A. V., Novikova, I. N., Zhu, S., Nabi, G., Litvinova, K. S., Baklanova, A. P., Bakshaliev, R. M., & Ravcheev, S. A. (2014). Evaluating adaptation options of microcirculatory-tissue systems based on the physiological link of nutritive blood flow and redox ratio. In E. A. Genina, V. L. Derbov, K. V. Larin, D. E. Postnov, & V. V. Tuchin (Eds.), Saratov Fall Meeting 2014 : Optical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics [944803] (Proceedings of SPIE; Vol. 9448), (Progress in Biomedical Optics and Imaging; Vol. 16, No. 53). SPIE-International Society for Optical Engineering. https://doi.org/10.1117/12.2179560