Evaluation and treatment of familial globozoospermia in five brothers

Zaid Kilani, Radwan Ismail, Samer Ghunaim, Hossam Mohamed, Ian Brewis, Christopher L. R. Barratt (Lead / Corresponding author), David Hughes

Research output: Contribution to journalArticlepeer-review

76 Citations (Scopus)


OBJECTIVE: To document the pathology of five siblings with complete globozoospermia and to report the effectiveness of repeated intracytoplasmic sperm injection (ICSI) treatment as therapy.

DESIGN: Case report.

SETTING: A tertiary center for assisted reproduction.

PATIENTS(S): Five siblings with globozoospermia.

INTERVENTION(S): Twenty cycles of repeated ICSI treatment. Detailed light and electron microscopy studies were performed on three of the globozoospermic brothers.

MAIN OUTCOME MEASURE(S): Clinical pregnancy and live birth after ICSI treatment.

RESULT(S): Light and electron microscopy showed that all spermatozoa had round heads and no acrosome. Of 129 metaphase-II oocytes injected, 49 fertilized normally, giving an overall fertilization rate of 38% (range, 0-100%). No pregnancies resulted from 13 cycles in brothers 1-3. Brothers 4 and 5 had three pregnancies after seven ICSI cycles, with one live birth and two first-trimester losses.

CONCLUSION(S): Despite variable fertilization rates, pregnancies and a live birth can be achieved after repeated ICSI treatment cycles in globozoospermic siblings. No apparent pattern was manifest that reflected the true pathology or determined the outcome of ICSI treatment.

Original languageEnglish
Pages (from-to)1436-1439
Number of pages4
JournalFertility and Sterility
Issue number5
Publication statusPublished - Nov 2004


  • Abortion, Spontaneous
  • Acrosome Reaction
  • Adult
  • Congenital Abnormalities/diagnosis
  • Embryo Transfer
  • Female
  • Humans
  • Infertility, Male/genetics
  • Male
  • Microscopy, Electron
  • Ovulation Induction
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy Rate
  • Siblings
  • Sperm Injections, Intracytoplasmic
  • Spermatozoa/abnormalities


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