Evaluation and treatment of familial globozoospermia in five brothers

Zaid Kilani; Radwan Ismail; Samer Ghunaim; Hossam Mohamed; Ian Brewis; Christopher L. R. Barratt; David  Hughes

doi:10.1016/j.fertnstert.2004.03.064

Evaluation and treatment of familial globozoospermia in five brothers

Zaid Kilani, Radwan Ismail, Samer Ghunaim, Hossam Mohamed, Ian Brewis, Christopher L. R. Barratt (Lead / Corresponding author), David Hughes

Undergraduate Medicine

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

OBJECTIVE: To document the pathology of five siblings with complete globozoospermia and to report the effectiveness of repeated intracytoplasmic sperm injection (ICSI) treatment as therapy.

DESIGN: Case report.

SETTING: A tertiary center for assisted reproduction.

PATIENTS(S): Five siblings with globozoospermia.

INTERVENTION(S): Twenty cycles of repeated ICSI treatment. Detailed light and electron microscopy studies were performed on three of the globozoospermic brothers.

MAIN OUTCOME MEASURE(S): Clinical pregnancy and live birth after ICSI treatment.

RESULT(S): Light and electron microscopy showed that all spermatozoa had round heads and no acrosome. Of 129 metaphase-II oocytes injected, 49 fertilized normally, giving an overall fertilization rate of 38% (range, 0-100%). No pregnancies resulted from 13 cycles in brothers 1-3. Brothers 4 and 5 had three pregnancies after seven ICSI cycles, with one live birth and two first-trimester losses.

CONCLUSION(S): Despite variable fertilization rates, pregnancies and a live birth can be achieved after repeated ICSI treatment cycles in globozoospermic siblings. No apparent pattern was manifest that reflected the true pathology or determined the outcome of ICSI treatment.

Original language	English
Pages (from-to)	1436-1439
Number of pages	4
Journal	Fertility and Sterility
Volume	82
Issue number	5
DOIs	https://doi.org/10.1016/j.fertnstert.2004.03.064
Publication status	Published - Nov 2004

Keywords

Abortion, Spontaneous
Acrosome Reaction
Adult
Congenital Abnormalities/diagnosis
Embryo Transfer
Female
Humans
Infertility, Male/genetics
Male
Microscopy, Electron
Ovulation Induction
Pregnancy
Pregnancy Outcome
Pregnancy Rate
Siblings
Sperm Injections, Intracytoplasmic
Spermatozoa/abnormalities

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10.1016/j.fertnstert.2004.03.064

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title = "Evaluation and treatment of familial globozoospermia in five brothers",

abstract = "OBJECTIVE: To document the pathology of five siblings with complete globozoospermia and to report the effectiveness of repeated intracytoplasmic sperm injection (ICSI) treatment as therapy.DESIGN: Case report.SETTING: A tertiary center for assisted reproduction.PATIENTS(S): Five siblings with globozoospermia.INTERVENTION(S): Twenty cycles of repeated ICSI treatment. Detailed light and electron microscopy studies were performed on three of the globozoospermic brothers.MAIN OUTCOME MEASURE(S): Clinical pregnancy and live birth after ICSI treatment.RESULT(S): Light and electron microscopy showed that all spermatozoa had round heads and no acrosome. Of 129 metaphase-II oocytes injected, 49 fertilized normally, giving an overall fertilization rate of 38% (range, 0-100%). No pregnancies resulted from 13 cycles in brothers 1-3. Brothers 4 and 5 had three pregnancies after seven ICSI cycles, with one live birth and two first-trimester losses.CONCLUSION(S): Despite variable fertilization rates, pregnancies and a live birth can be achieved after repeated ICSI treatment cycles in globozoospermic siblings. No apparent pattern was manifest that reflected the true pathology or determined the outcome of ICSI treatment.",

keywords = "Abortion, Spontaneous, Acrosome Reaction, Adult, Congenital Abnormalities/diagnosis, Embryo Transfer, Female, Humans, Infertility, Male/genetics, Male, Microscopy, Electron, Ovulation Induction, Pregnancy, Pregnancy Outcome, Pregnancy Rate, Siblings, Sperm Injections, Intracytoplasmic, Spermatozoa/abnormalities",

author = "Zaid Kilani and Radwan Ismail and Samer Ghunaim and Hossam Mohamed and Ian Brewis and Barratt, {Christopher L. R.} and David Hughes",

year = "2004",

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T1 - Evaluation and treatment of familial globozoospermia in five brothers

AU - Kilani, Zaid

AU - Ismail, Radwan

AU - Ghunaim, Samer

AU - Mohamed, Hossam

AU - Brewis, Ian

AU - Barratt, Christopher L. R.

AU - Hughes, David

PY - 2004/11

Y1 - 2004/11

N2 - OBJECTIVE: To document the pathology of five siblings with complete globozoospermia and to report the effectiveness of repeated intracytoplasmic sperm injection (ICSI) treatment as therapy.DESIGN: Case report.SETTING: A tertiary center for assisted reproduction.PATIENTS(S): Five siblings with globozoospermia.INTERVENTION(S): Twenty cycles of repeated ICSI treatment. Detailed light and electron microscopy studies were performed on three of the globozoospermic brothers.MAIN OUTCOME MEASURE(S): Clinical pregnancy and live birth after ICSI treatment.RESULT(S): Light and electron microscopy showed that all spermatozoa had round heads and no acrosome. Of 129 metaphase-II oocytes injected, 49 fertilized normally, giving an overall fertilization rate of 38% (range, 0-100%). No pregnancies resulted from 13 cycles in brothers 1-3. Brothers 4 and 5 had three pregnancies after seven ICSI cycles, with one live birth and two first-trimester losses.CONCLUSION(S): Despite variable fertilization rates, pregnancies and a live birth can be achieved after repeated ICSI treatment cycles in globozoospermic siblings. No apparent pattern was manifest that reflected the true pathology or determined the outcome of ICSI treatment.

AB - OBJECTIVE: To document the pathology of five siblings with complete globozoospermia and to report the effectiveness of repeated intracytoplasmic sperm injection (ICSI) treatment as therapy.DESIGN: Case report.SETTING: A tertiary center for assisted reproduction.PATIENTS(S): Five siblings with globozoospermia.INTERVENTION(S): Twenty cycles of repeated ICSI treatment. Detailed light and electron microscopy studies were performed on three of the globozoospermic brothers.MAIN OUTCOME MEASURE(S): Clinical pregnancy and live birth after ICSI treatment.RESULT(S): Light and electron microscopy showed that all spermatozoa had round heads and no acrosome. Of 129 metaphase-II oocytes injected, 49 fertilized normally, giving an overall fertilization rate of 38% (range, 0-100%). No pregnancies resulted from 13 cycles in brothers 1-3. Brothers 4 and 5 had three pregnancies after seven ICSI cycles, with one live birth and two first-trimester losses.CONCLUSION(S): Despite variable fertilization rates, pregnancies and a live birth can be achieved after repeated ICSI treatment cycles in globozoospermic siblings. No apparent pattern was manifest that reflected the true pathology or determined the outcome of ICSI treatment.

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KW - Congenital Abnormalities/diagnosis

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KW - Female

KW - Humans

KW - Infertility, Male/genetics

KW - Male

KW - Microscopy, Electron

KW - Ovulation Induction

KW - Pregnancy

KW - Pregnancy Outcome

KW - Pregnancy Rate

KW - Siblings

KW - Sperm Injections, Intracytoplasmic

KW - Spermatozoa/abnormalities

U2 - 10.1016/j.fertnstert.2004.03.064

DO - 10.1016/j.fertnstert.2004.03.064

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SP - 1436

EP - 1439

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 5

ER -

Evaluation and treatment of familial globozoospermia in five brothers

Abstract

Keywords

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