OBJECTIVE: To document the pathology of five siblings with complete globozoospermia and to report the effectiveness of repeated intracytoplasmic sperm injection (ICSI) treatment as therapy.
DESIGN: Case report.
SETTING: A tertiary center for assisted reproduction.
PATIENTS(S): Five siblings with globozoospermia.
INTERVENTION(S): Twenty cycles of repeated ICSI treatment. Detailed light and electron microscopy studies were performed on three of the globozoospermic brothers.
MAIN OUTCOME MEASURE(S): Clinical pregnancy and live birth after ICSI treatment.
RESULT(S): Light and electron microscopy showed that all spermatozoa had round heads and no acrosome. Of 129 metaphase-II oocytes injected, 49 fertilized normally, giving an overall fertilization rate of 38% (range, 0-100%). No pregnancies resulted from 13 cycles in brothers 1-3. Brothers 4 and 5 had three pregnancies after seven ICSI cycles, with one live birth and two first-trimester losses.
CONCLUSION(S): Despite variable fertilization rates, pregnancies and a live birth can be achieved after repeated ICSI treatment cycles in globozoospermic siblings. No apparent pattern was manifest that reflected the true pathology or determined the outcome of ICSI treatment.
- Abortion, Spontaneous
- Acrosome Reaction
- Congenital Abnormalities/diagnosis
- Embryo Transfer
- Infertility, Male/genetics
- Microscopy, Electron
- Ovulation Induction
- Pregnancy Outcome
- Pregnancy Rate
- Sperm Injections, Intracytoplasmic