Evaluation and treatment of familial globozoospermia in five brothers

Zaid Kilani, Radwan Ismail, Samer Ghunaim, Hossam Mohamed, Ian Brewis, Christopher L. R. Barratt (Lead / Corresponding author), David Hughes

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

OBJECTIVE: To document the pathology of five siblings with complete globozoospermia and to report the effectiveness of repeated intracytoplasmic sperm injection (ICSI) treatment as therapy.

DESIGN: Case report.

SETTING: A tertiary center for assisted reproduction.

PATIENTS(S): Five siblings with globozoospermia.

INTERVENTION(S): Twenty cycles of repeated ICSI treatment. Detailed light and electron microscopy studies were performed on three of the globozoospermic brothers.

MAIN OUTCOME MEASURE(S): Clinical pregnancy and live birth after ICSI treatment.

RESULT(S): Light and electron microscopy showed that all spermatozoa had round heads and no acrosome. Of 129 metaphase-II oocytes injected, 49 fertilized normally, giving an overall fertilization rate of 38% (range, 0-100%). No pregnancies resulted from 13 cycles in brothers 1-3. Brothers 4 and 5 had three pregnancies after seven ICSI cycles, with one live birth and two first-trimester losses.

CONCLUSION(S): Despite variable fertilization rates, pregnancies and a live birth can be achieved after repeated ICSI treatment cycles in globozoospermic siblings. No apparent pattern was manifest that reflected the true pathology or determined the outcome of ICSI treatment.

Original languageEnglish
Pages (from-to)1436-1439
Number of pages4
JournalFertility and Sterility
Volume82
Issue number5
DOIs
Publication statusPublished - Nov 2004

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Intracytoplasmic Sperm Injections
Live Birth
Fertilization
Pregnancy
Electron Microscopy
Therapeutics
Pathology
Light
Acrosome
Pregnancy Rate
First Pregnancy Trimester
Metaphase
Oocytes
Reproduction
Spermatozoa
Teratozoospermia
Head

Keywords

  • Abortion, Spontaneous
  • Acrosome Reaction
  • Adult
  • Congenital Abnormalities/diagnosis
  • Embryo Transfer
  • Female
  • Humans
  • Infertility, Male/genetics
  • Male
  • Microscopy, Electron
  • Ovulation Induction
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy Rate
  • Siblings
  • Sperm Injections, Intracytoplasmic
  • Spermatozoa/abnormalities

Cite this

Kilani, Zaid ; Ismail, Radwan ; Ghunaim, Samer ; Mohamed, Hossam ; Brewis, Ian ; Barratt, Christopher L. R. ; Hughes, David . / Evaluation and treatment of familial globozoospermia in five brothers. In: Fertility and Sterility. 2004 ; Vol. 82, No. 5. pp. 1436-1439.
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Kilani, Z, Ismail, R, Ghunaim, S, Mohamed, H, Brewis, I, Barratt, CLR & Hughes, D 2004, 'Evaluation and treatment of familial globozoospermia in five brothers', Fertility and Sterility, vol. 82, no. 5, pp. 1436-1439. https://doi.org/10.1016/j.fertnstert.2004.03.064

Evaluation and treatment of familial globozoospermia in five brothers. / Kilani, Zaid; Ismail, Radwan; Ghunaim, Samer; Mohamed, Hossam; Brewis, Ian; Barratt, Christopher L. R. (Lead / Corresponding author); Hughes, David .

In: Fertility and Sterility, Vol. 82, No. 5, 11.2004, p. 1436-1439.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation and treatment of familial globozoospermia in five brothers

AU - Kilani, Zaid

AU - Ismail, Radwan

AU - Ghunaim, Samer

AU - Mohamed, Hossam

AU - Brewis, Ian

AU - Barratt, Christopher L. R.

AU - Hughes, David

PY - 2004/11

Y1 - 2004/11

N2 - OBJECTIVE: To document the pathology of five siblings with complete globozoospermia and to report the effectiveness of repeated intracytoplasmic sperm injection (ICSI) treatment as therapy.DESIGN: Case report.SETTING: A tertiary center for assisted reproduction.PATIENTS(S): Five siblings with globozoospermia.INTERVENTION(S): Twenty cycles of repeated ICSI treatment. Detailed light and electron microscopy studies were performed on three of the globozoospermic brothers.MAIN OUTCOME MEASURE(S): Clinical pregnancy and live birth after ICSI treatment.RESULT(S): Light and electron microscopy showed that all spermatozoa had round heads and no acrosome. Of 129 metaphase-II oocytes injected, 49 fertilized normally, giving an overall fertilization rate of 38% (range, 0-100%). No pregnancies resulted from 13 cycles in brothers 1-3. Brothers 4 and 5 had three pregnancies after seven ICSI cycles, with one live birth and two first-trimester losses.CONCLUSION(S): Despite variable fertilization rates, pregnancies and a live birth can be achieved after repeated ICSI treatment cycles in globozoospermic siblings. No apparent pattern was manifest that reflected the true pathology or determined the outcome of ICSI treatment.

AB - OBJECTIVE: To document the pathology of five siblings with complete globozoospermia and to report the effectiveness of repeated intracytoplasmic sperm injection (ICSI) treatment as therapy.DESIGN: Case report.SETTING: A tertiary center for assisted reproduction.PATIENTS(S): Five siblings with globozoospermia.INTERVENTION(S): Twenty cycles of repeated ICSI treatment. Detailed light and electron microscopy studies were performed on three of the globozoospermic brothers.MAIN OUTCOME MEASURE(S): Clinical pregnancy and live birth after ICSI treatment.RESULT(S): Light and electron microscopy showed that all spermatozoa had round heads and no acrosome. Of 129 metaphase-II oocytes injected, 49 fertilized normally, giving an overall fertilization rate of 38% (range, 0-100%). No pregnancies resulted from 13 cycles in brothers 1-3. Brothers 4 and 5 had three pregnancies after seven ICSI cycles, with one live birth and two first-trimester losses.CONCLUSION(S): Despite variable fertilization rates, pregnancies and a live birth can be achieved after repeated ICSI treatment cycles in globozoospermic siblings. No apparent pattern was manifest that reflected the true pathology or determined the outcome of ICSI treatment.

KW - Abortion, Spontaneous

KW - Acrosome Reaction

KW - Adult

KW - Congenital Abnormalities/diagnosis

KW - Embryo Transfer

KW - Female

KW - Humans

KW - Infertility, Male/genetics

KW - Male

KW - Microscopy, Electron

KW - Ovulation Induction

KW - Pregnancy

KW - Pregnancy Outcome

KW - Pregnancy Rate

KW - Siblings

KW - Sperm Injections, Intracytoplasmic

KW - Spermatozoa/abnormalities

U2 - 10.1016/j.fertnstert.2004.03.064

DO - 10.1016/j.fertnstert.2004.03.064

M3 - Article

VL - 82

SP - 1436

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JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 5

ER -