Evaluation of PAX3 genetic variants and nevus number

Zighereda Ogbah (Lead / Corresponding author), Celia Badenas, Mark Harland, Joan A. Puig-Butille, Fay Elliot, Nuria Bonifaci, Elisabet Guino, Julie Randerson-Moor, May Chan, Mark M. Iles, Daniel Glass, Andrew A. Brown, Cristina Carrera, Isabel Kolm, Veronique Bataille, Timothy D. Spector, Josep Malvehy, Julia Newton-Bishop, Miquel A. Pujana, Tim BishopSusana Puig

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The presence of a high nevus number is the strongest phenotypic predictor of melanoma risk. Here, we describe the results of a three-stage study directed at identifying risk variants for the high nevus phenotype. At the first stage, 263 melanoma cases from Barcelona were genotyped for 223 single-nucleotide polymorphisms (SNPs) in 39 candidate genes. Seven SNPs in the PAX3 gene were found to be significantly associated with nevus number under the additive model. Next, the associations for seven PAX3 variants were evaluated in 1217 melanoma cases and 475 controls from Leeds; and in 3054 healthy twins from TwinsUK. Associations with high nevus number were detected for rs6754024 (P values < 0.01) in the Barcelona and Leeds datasets and for rs2855268 (P values < 0.01) in the Barcelona and the TwinsUK sets. Associations (P values < 0.001) in the opposite direction were detected for rs7600206 and rs12995399 in the Barcelona and TwinsUK sets. This study suggests that SNPs in PAX3 are associated with nevus number, providing support for PAX3 as a candidate nevus gene. Further studies are needed to examine the role of PAX3 in melanoma susceptibility.

Original languageEnglish
Pages (from-to)666-676
Number of pages11
JournalPigment Cell and Melanoma Research
Volume26
Issue number5
DOIs
Publication statusPublished - Sep 2013

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Middle Aged
  • Nevus/genetics
  • PAX3 Transcription Factor
  • Paired Box Transcription Factors/genetics
  • Polymorphism, Single Nucleotide/genetics
  • Skin Neoplasms/genetics
  • Spain
  • United Kingdom
  • Young Adult

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  • Cite this

    Ogbah, Z., Badenas, C., Harland, M., Puig-Butille, J. A., Elliot, F., Bonifaci, N., Guino, E., Randerson-Moor, J., Chan, M., Iles, M. M., Glass, D., Brown, A. A., Carrera, C., Kolm, I., Bataille, V., Spector, T. D., Malvehy, J., Newton-Bishop, J., Pujana, M. A., ... Puig, S. (2013). Evaluation of PAX3 genetic variants and nevus number. Pigment Cell and Melanoma Research, 26(5), 666-676. https://doi.org/10.1111/pcmr.12130